ArticleSleep & breathing = Schlaf & Atmung2012
Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apnea.
Article in Sleep & breathing = Schlaf & Atmung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis.Oncotarget · 2017Pooled it
- Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Evaluation and diagnosis of pediatric obstructive sleep apnea-An update.Frontiers in sleep · 2023Review
- Visceral adiposity is related to insulin sensitivity and inflammation in adolescents with obesity and mild sleep disordered breathing.Journal of pediatric endocrinology & metabolism : JPEM · 2022Article
- Liver X Receptor Gene Expression is Enhanced in Children with Obstructive Sleep Apnea-Hyperpnoea Syndrome and Cyclooxygenase-2 (COX-2) is Correlated with Severity of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Review
- Role of sleep quality in the metabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2016Review
- Biomarkers associated with obstructive sleep apnea: A scoping review.Sleep medicine reviews · 2015Article
- Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers.Pediatric obesity · 2014Article
- Improving Positive Airway Pressure Adherence in Children.Sleep medicine clinics · 2014Article
- Inflammatory markers and obstructive sleep apnea in obese children: the NANOS study.Mediators of inflammation · 2014Article
- Death by a thousand cuts in Alzheimer's disease: hypoxia--the prodrome.Neurotoxicity research · 2013Review
- Does physical exercise reduce excessive daytime sleepiness by improving inflammatory profiles in obstructive sleep apnea patients?Sleep & breathing = Schlaf & Atmung · 2013Review
- Chemoreceptors, baroreceptors, and autonomic deregulation in children with obstructive sleep apnea.Respiratory physiology & neurobiology · 2013Review
- Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.Neurochemical research · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeObstructive sleep apnea (OSA) in children is associated with obesity, insulin resistance, and elevated baseline inflammation as measured by high-sensitivity C-reactive protein (hsCRP). Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance.
methodsTwenty-three children with clinical suspicion of OSA underwent a sleep study. Levels of hsCRP were tested the evening before and morning after the sleep study. Fasting insulin and glucose levels were measured from which the homeostasis model of insulin resistance (HOMA-IR) was calculated. Linear correlations were performed to evaluate relationships between hsCRP levels at baseline and change overnight (ΔhsCRP) vs. HOMA-IR, body mass index (BMI) z-score, and sleep study parameters related to O(2) saturation and the apnea-hypopnea index (AHI).
resultsAmong children with OSA and the entire cohort, hsCRP values were correlated with HOMA-IR and BMI z-scores. HOMA-IR but not BMI z-score correlated with ΔhsCRP overnight in the entire cohort. Sleep study parameters, including AHI mean O(2) saturation overnight, REM O(2) nadir, and non-REM O(2) nadir were not correlated with hsCRP or ΔhsCRP overnight.
conclusionAmong children being evaluated for OSA, degree of insulin resistance may be an important determinant of increased systemic inflammation overnight. Sleep study markers did not correlate with ΔhsCRP, leaving uncertain the role of OSA in increasing inflammation overnight. Further studies are needed to explore these associations and their potential mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.