ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2011
The effectiveness of the new (7th) UICC N classification in the prognosis evaluation of gastric cancer patients: a comparative study between the 5th/6th and 7th UICC N classification.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
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- Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- The potential role of tumor deposits in the prognosis and TNM staging for colorectal cancer.Journal of gastrointestinal oncology · 2024Article
- Machine learning methods predict recurrence of pN3b gastric cancer after radical resection.Translational cancer research · 2024Article
- Prognostic value of lymph node density on cancer staging system for gastric cancer without distal metastasis: a population-based analysis of SEER database.World journal of surgical oncology · 2022Article
- Prognostic value of preoperative body mass index for diabetic patients with non-metastasis gastric cancer: a single center experience.BMC surgery · 2021Article
- Development and validation of a novel staging system integrating the number and location of lymph nodes for gastric adenocarcinoma.British journal of cancer · 2021Article
- Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Tumor deposit serves as a prognostic marker in gastric cancer: A propensity score-matched analysis comparing survival outcomes.Cancer medicine · 2020Article
- Nesfatin-1 is a potential diagnostic biomarker for gastric cancer.Oncology letters · 2020Article
- Establishment and Applicability of a Diagnostic System for Advanced Gastric Cancer T Staging Based on a Faster Region-Based Convolutional Neural Network.Frontiers in oncology · 2020Article
- Multicenter Validation Study of the American Joint Commission on Cancer (8th Edition) for Gastric Cancer: Proposal for a Simplified and Improved TNM Staging System.Journal of Cancer · 2020Article
- Development and validation of a novel nomogram to predict overall survival in gastric cancer with lymph node metastasis.International journal of biological sciences · 2020Article
- CT findings in diagnosis of gastric bare area invasion: potential prognostic factors for proximal gastric carcinoma.Japanese journal of radiology · 2019Article
- New metastatic lymph node classification for early gastric cancer should differ from those for advanced gastric adenocarcinoma: Results based on the SEER database.World journal of clinical cases · 2019Article
- Adjuvant chemoradiotherapy versus adjuvant chemotherapy for patients with N3 gastric cancer after D2/R0 resection: a retrospective study based on propensity score analyses.Cancer management and research · 2019Article
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- Improvements to the gastric cancer tumor-node-metastasis staging system based on computer-aided unsupervised clustering.BMC cancer · 2018Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundThe most important prognostic factor after curative surgery for gastric carcinoma is the presence of lymph node metastases. According to the 7th edition of the UICC TNM staging system for gastric cancer, N classification was categorized as N0 (no regional lymph node metastasis), N1 (1-2 regional lymph node metastases), N2 (3-6 regional lymph node metastases), and N3 (7 or more regional lymph node metastases). The purpose of this study was to evaluate the rationality of the new UICC/AJCC N classification in comparison with the 6th UICC classification.
methodsFrom August 2002 to July 2006, 295 patients with gastric cancer underwent curative resection with D2 lymph node dissection by a single surgeon. We analyzed retrospectively the significant prognostic factors and identified the suitability of the 7th UICC N staging system.
resultsAccording to the 7th UICC N classification, the 5-year cumulative survival rates (5-YSR) of N0, N1, N2, N3a, and N3b were 89.7, 73.6, 54.9, 23.1, and 5.4%, respectively (P < 0.0001). Using univariate analysis, the N classification of the 7th and 6th UICC/AJCC TNM staging system, T classification of the 7th UICC TNM staging system, size and location of tumor, and histology were associated with the overall survival of gastric cancer after curative surgery. However, Cox regression multivariate analysis showed the 7th UICC N classification was an independent prognostic factor instead of the 6th UICC N classification (P < 0.0001).
conclusionThe 7th UICC classification for lymph node metastasis is thought to be a more reliable prognostic factor for gastric cancer than the 6th classification.
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