Evidence map›Paper›PMID 21360125›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011

Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial.

Nikica Darabos, Miroslav Haspl, Carsten Moser, Anela Darabos, Dubravka Bartolek, Dietrich Groenemeyer

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  4. Platelet-rich plasma: does it help reduce tunnel widening after ACL reconstruction?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013
    Trial
  5. Orthobiologics in anterior cruciate ligament injuries.Journal of experimental orthopaedics · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Nikica DarabosUniversity Clinic for Traumatology, Medical School, University of Zagreb, Draskoviceva 19, 10000, Zagreb, Croatia. darabos.dr@vz.t-com.hr
Miroslav Haspl
Carsten Moser
Anela Darabos
Dubravka Bartolek
Dietrich Groenemeyer
Grönemeyer Institute for MicroTherapy · DEUniversity of Zagreb · HRLabCorp (United States) · USOpća Bolnica Varaždin · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePro-inflammatory cytokines play a pivotal role in osteoarthritis, as well as in bone tunnel widening after ACL reconstructive surgery. A new treatment option is to administer autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and growth factors (IGF-1, PDGF, and TGF-β1, among others) in the liquid blood phase. The purpose of this trial was to establish whether the postoperative outcome could be affected by intraarticular application of ACS.

methodsIn a prospective, randomized, double-blinded, placebo-controlled trial with two parallel groups, 62 patients were treated. Bone tunnel width was measured by CT scans, while clinical efficacy was assessed by patient-administered outcome instruments (WOMAC, IKDC 2000) up to 1 year following the ACL reconstruction in patients receiving either ACS (Group A) or placebo (Group B). We compared the levels and dynamics of IL-1β concentrations in the synovial liquid and examined the correlation between the levels of IL-1β at three different postoperative points.

resultsBone tunnel enlargement was significantly less (6 months: 8%, 12 months: 13%) in Group A than in Group B (6 months: 31%, 12 months: 38%). Clinical outcomes (WOMAC, IKDC 2000) were consistently better in patients treated with ACS at all data points and for all outcome parameters, and there were statistically significant differences in the WOMAC stiffness subscale after 1 year. The decrease in IL-1β synovial fluid concentration was more pronounced in the ACS group, and values were lower, to a statistically significant degree, in the ACS group at day 10.

conclusionThe intraarticular administration/injection of ACS results in decreased bone tunnel widening after ACL reconstructive surgery.

Indexed as

Blood Transfusion, AutologousAdultAnalysis of VarianceAnterior Cruciate Ligament ReconstructionChi-Square DistributionDouble-Blind MethodFemaleHumansInterleukin-1betaMalePlacebosProspective StudiesRange of Motion, ArticularSerumSynovial FluidTomography, X-Ray ComputedInterleukin-1betaPlacebos

Identifiers

PMID21360125
OpenAlexW2014637904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.