Evidence map›Paper›PMID 21359973›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2011

Transcriptional regulation and multiple functions of MAO genes.

Jean C Shih, Jason Boyang Wu, Kevin Chen

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Review
  6. Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  7. Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jean C ShihDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Room 518, Los Angeles, CA 90089, USA. jcshih@usc.edu
Jason Boyang Wu
Kevin Chen
University of Southern California · US

Funding

TWO TYPES OF MONOAMINE OXIDASER37MH039085 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHIH, JEAN CHEN · 1988 to 2007
$3.8M
TWO TYPES OF MONOAMINE OXIDASER01MH039085 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHIH, JEAN CHEN · 1985 to 2013
$2.0M
THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE AR01MH067968 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHIH, JEAN CHEN · 2004 to 2008
$1.8M
NIMH NIH HHS R01 MH039085NIMH NIH HHS R01 MH067968NIMH NIH HHS R01MH67968NIMH NIH HHS R37 MH039085NIMH NIH HHS R37MH39085
6 · The paper itself

Abstract

Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. These two isoenzymes have different but overlapping substrate and inhibitor specificities. MAO A and MAO B share 70% amino acid sequence identity and show different temporal and spatial expressions in both humans and mice. Abnormal MAO A or MAO B activity has been implicated in numerous neurological and psychiatric disorders. A better understanding of the transcriptional regulation of MAO A and MAO B genes may help explain the differential tissue-specific expression of these two isoenzymes and provide insights into the molecular basis of the disorders associated with MAO dysfunction. This review discusses the recent progress in the transcriptional regulation and multiple functions of MAO A and MAO B genes.

Indexed as

AnimalsGene Expression Regulation, EnzymologicHumansIsoenzymesMonoamine OxidaseOrgan SpecificityPromoter Regions, GeneticSignal TransductionTranscriptional ActivationTranscription, GeneticIsoenzymesMonoamine Oxidase

Identifiers

PMID21359973
PMCPMC3125068
OpenAlexW2004185567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.