ArticleSurgical endoscopy2011
Day-to-day discrepancy in Bravo pH monitoring is related to the degree of deterioration of the lower esophageal sphincter and severity of reflux disease.
Article in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- First agreement analysis and day-to-day comparison of pharyngeal pH monitoring with pH/impedance monitoring in patients with suspected laryngopharyngeal reflux.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Trial
- Reflections on surgery for hiatal hernia.Updates in surgery · 2026Review
- Can the Mean Nocturnal Baseline Impedance/Acid Exposure Time Ratio Serve as a Novel Parameter for the Definitive Diagnosis of Pathological Reflux?Journal of clinical medicine · 2025Article
- Utility of pH monitoring in surgical decision-making and outcome prediction in revisional antireflux surgery for anatomical failure.Surgical endoscopy · 2025Article
- Current status of functional testing for upper gastrointestinal disorders: state-of-the-art review.Singapore medical journal · 2025Review
- Prolonged acid reflux monitoring using acid exposure time and DeMeester score: two days are not enough.Surgical endoscopy · 2024Article
- Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease.International journal of biological sciences · 2021Review
- Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders.Gastroenterology · 2019Article
- Does anti-reflux surgery disrupt the pathway of Barrett's esophagus progression to cancer?Translational gastroenterology and hepatology · 2018Review
- Evaluation of Gastroesophageal Reflux Disease Using the Bravo Capsule pH System.Journal of neurogastroenterology and motility · 2016Article
- 24-h multichannel intraluminal impedance-pH monitoring may be an inadequate test for detecting gastroesophageal reflux in patients with mixed typical and atypical symptoms.Surgical endoscopy · 2015Article
- Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors.BMC gastroenterology · 2014Article
- Early referral for 24-h esophageal pH monitoring may prevent unnecessary treatment with acid-reducing medications.Surgical endoscopy · 2013Article
- Esophagogastroduodenoscopy with conscious sedation does not interfere with catheter-based 24-h pH monitoring.World journal of gastroenterology · 2013Article
- Intraluminal pH and goblet cell density in Barrett's esophagus.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Bravo capsule allows monitoring of esophageal acid exposure over a two-day period. Experience has shown that 24-32% of patients will have abnormal esophageal acid exposure detected on only one of the 2 days monitored. This variation has been explained by the effect of endoscopy and sedation. The aim of this study was to assess the day-to-day discrepancy following transnasal placement of the Bravo capsule without endoscopy or sedation and to determine factors related to this variability.
methodsBravo pH monitoring was performed by transnasal placement of the capsule in 310 patients. Patients were divided into groups based on the composite pH score: both days normal, both days abnormal and only one of the 2 days abnormal. Lower esophageal sphincter (LES) characteristics were compared between groups.
resultsOf the 310 patients evaluated, 60 (19%) showed a discrepancy between the 2 days. A total of 127 patients had a normal pH score on both days and 123 had an abnormal pH score on both days. Of the 60 patients with a discrepancy, 27 were abnormal the first day and 33 (55%) were abnormal the second day. Patients with abnormal esophageal acid exposure on both days had higher degrees of esophageal acid exposure and were more likely to have a defective LES compared to those with an abnormal score on only one day (35 vs. 83%, p=0.027).
conclusionPatients with a discrepancy between days of Bravo pH monitoring have lower esophageal acid exposure. Variability between the 2 days represents early deterioration of the gastroesophageal barrier and indicates less advanced reflux disease.
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