ArticleMedical oncology (Northwood, London, England)2012
Telomere shortening occurs early during gastrocarcinogenesis.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer.Cancers · 2024Review
- Telomere Attrition With Concomitant hTERT Overexpression Involved in the Progression of Gastric Cancer May Have Prognostic and Clinical Implications in High-Risk Population Group From North India.Frontiers in oncology · 2022Article
- Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions.International journal of molecular sciences · 2021Review
- Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Article
- Telomere length in the gastric mucosa after Helicobacter pylori eradication and its potential role in the gastric carcinogenesis.Clinical and experimental medicine · 2018Article
- Association between clincopathological characteristics and hTERT expression as well as telomere length in ameloblastoma.International journal of clinical and experimental pathology · 2017Article
- Association of telomere length in peripheral leukocytes with chronic hepatitis B and hepatocellular carcinoma.Medicine · 2016Article
- Telomere length shortening in gastric mucosa is a field effect associated with increased risk of gastric cancer.Virchows Archiv : an international journal of pathology · 2016Article
- Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood.PloS one · 2015Article
- Telomeres and telomere dynamics: relevance to cancers of the GI tract.Expert review of gastroenterology & hepatology · 2013Review
- Telomere shortening and Alzheimer's disease.Neuromolecular medicine · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When telomeres are shortened to a critical length, they will initiate chromosomal instability (CIN) and may finally cause tumorigenesis. The purpose of the present study was to evaluate the shortened telomere as a potential biomarker for tumorigenesis in gastric carcinoma. The telomeres in matched cancer and adjacent noncancer mucosa samples from 86 gastric carcinoma patients were measured by real-time polymerase chain reaction (PCR). According to the International Union Against Cancer (UICC), tumor stages were classified into four groups: stage I (n = 23), stage II (n = 20), stage III (n = 23), and stage IV (n = 20). Telomere length decreased with aging in both adjacent noncancer mucosa and cancer tissue (r = -0.261 (P = 0.008) and r = -0.27 (P = 0.012), respectively). The telomere length of UICC stage I tumors was significantly shorter than the average telomere length in adjacent noncancer mucosa (P = 0.023). Telomere length increased gradually with increasing UICC stage (P = 0.032). The telomere length of UICC stage IV tumors was significantly longer, when compared to that in noncancer mucosa (P = 0.019) and stage I tumors (P = 0.002). In summary, telomere length undergoes shortening in early stage gastric carcinoma and lengthening in advanced gastric carcinoma. Additionally, telomere shortening may initiate the tumorigenesis of gastric carcinoma.
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