ArticleJournal of mathematical biology2012
The effect of recurrent mutation on the linkage disequilibrium under a selective sweep.
Article in Journal of mathematical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Linkage disequilibrium between rare mutations.Genetics · 2022Article
- Elevated Linkage Disequilibrium and Signatures of Soft Sweeps Are Common in Drosophila melanogaster.Genetics · 2016Article
- A Coalescent Model for a Sweep of a Unique Standing Variant.Genetics · 2015Article
- Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps.PLoS genetics · 2015Article
- Population genomic analyses of early-phase Atlantic Salmon (Salmo salar) domestication/captive breeding.Evolutionary applications · 2015Article
- Population genomics of rapid adaptation by soft selective sweeps.Trends in ecology & evolution · 2013Review
- Evaluation of the hormonal state of columnar apple trees (Malus x domestica) based on high throughput gene expression studies.Plant molecular biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A selective sweep describes the reduction of diversity due to strong positive selection. If the mutation rate to a selectively beneficial allele is sufficiently high, Pennings and Hermisson (Mol Biol Evol 23(5):1076-1084, 2006a) have shown, that it becomes likely, that a selective sweep is caused by several individuals. Such an event is called a soft sweep and the complementary event of a single origin of the beneficial allele, the classical case, a hard sweep. We give analytical expressions for the linkage disequilibrium (LD) between two neutral loci linked to the selected locus, depending on the recurrent mutation to the beneficial allele, measured by D and ̂σ(2)(D), a quantity introduced by Ohta and Kimura (Genetics 63(1):229-238, 1969), and conclude that the LD-pattern of a soft sweep differs substantially from that of a hard sweep due to haplotype structure. The analytical results are compared with simulations.
Indexed as
Identifiers
21359840What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.