ArticleDiabetologia2011
The four-variable modification of diet in renal disease formula underestimates glomerular filtration rate in obese type 2 diabetic individuals with chronic kidney disease.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area.BMC nephrology · 2012Trial
- Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations?Diabetologia · 2011Trial
- The "obesity paradox" in dosing: a comprehensive analytical review of cockcroft-gault versus CKD-EPI for predicting clearance of narrow-therapeutic-index drugs in patients with BMI > 40 kg/m².European journal of clinical pharmacology · 2026Review
- Effect of Roux-En-Y Gastric Bypass on Albuminuria in Morbidly Obese Patients with Type-2 Diabetes Mellitus: A Prospective Non-Randomized Controlled Study with 15-Month Follow-Up.International journal of general medicine · 2026Article
- Association of British Clinical Diabetologists and UK Kidney Association Joint Clinical Practice Guidelines for the Pharmacological Management of Hyperglycemia in Adults With Type 2 Diabetes Mellitus and CKD.Kidney international reports · 2025Article
- Article
- Studying the effect of donor kidney volume ratios to recipients' body surface area, body mass index, and total body weight on post-transplant graft function.Abdominal radiology (New York) · 2023Article
- Assessment of renal impairment using estimated glomerular filtration rate among type 2 diabetes mellitus patients in North-East Ethiopia: a cross-sectional study.Journal of diabetes and metabolic disorders · 2020Article
- The Effect of Metabolic Surgery on the Complications of Diabetes: What Are the Unanswered Questions?Frontiers in endocrinology · 2020Review
- A Validation Study on eGFR Equations in Chinese Patients With Diabetic or Non-diabetic CKD.Frontiers in endocrinology · 2019Article
- Kidney Function in Obesity-Challenges in Indexing and Estimation.Advances in chronic kidney disease · 2018Review
- Metabolic and Hormonal Determinants of Glomerular Filtration Rate and Renal Hemodynamics in Severely Obese Individuals.Obesity facts · 2016Article
- Article
- Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis.BMC nephrology · 2015Article
- Development and validation of new glomerular filtration rate predicting models for Chinese patients with type 2 diabetes.Journal of translational medicine · 2015Article
- Article
- Estimated glomerular filtration rate and albuminuria: true predictors of cardiovascular events in obese patients with type 2 diabetes?Wiener klinische Wochenschrift · 2013Article
- Estimation of glomerular filtration rate by a radial basis function neural network in patients with type-2 diabetes mellitus.BMC nephrology · 2013Article
- GFR estimation in the morbidly obese pre- and postbariatric surgery: one size does not fit all.International urology and nephrology · 2013Article
- Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy?Diabetologia · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisGFR is commonly estimated using the four-variable Modification of Diet in Renal Disease (MDRD) formula and this forms the basis for classification of chronic kidney disease (CKD). We investigated the effect of obesity on the estimation of glomerular filtration rate in type 2 diabetic participants with CKD.
methodsWe enrolled 111 patients with type 2 diabetes mellitus in different stages of CKD. GFR was measured using (51)Cr-labelled EDTA plasma clearance and was estimated using the four-variable MDRD formula.
resultsThe bias between estimated and measured GFR was -22.4 (-33.8 to -11.0) p < 0.001 in the obese group compared with -6.04 (-17.6 to -5.5) p = 0.299 in the non-obese group. When GFR was indexed to body surface area of 1.73 m(2), the bias remained significant at -9.4 (-13.4 to -5.4) p < 0.001 in the obese participants. CONCLUSIONS/
interpretationThis study suggests that the four-variable MDRD formula significantly underestimates GFR in obese type 2 diabetic participants with CKD.
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