ArticlePloS one2011
Cooperative adaptation to establishment of a synthetic bacterial mutualism.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Advances in synthetic microbial ecosystems approach for studying ecological interactions and their influencing factors.Engineering microbiology · 2025Review
- Synthetic Ecosystems: From the Test Tube to the Biosphere.ACS synthetic biology · 2024Review
- Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems.Entropy (Basel, Switzerland) · 2023Article
- Indirect Enrichment of Desirable, but Less Fit Phenotypes, from a Synthetic Microbial Community Using Microdroplet Confinement.ACS synthetic biology · 2023Article
- Indirect enrichment of desirable, but less fit phenotypes, from a synthetic microbial community using microdroplet confinement.bioRxiv : the preprint server for biology · 2023Article
- Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia.Royal Society open science · 2022Article
- Article
- Automated design of synthetic microbial communities.Nature communications · 2021Article
- Article
- Fitness and Productivity Increase with Ecotypic Diversity amongApplied and environmental microbiology · 2020Article
- Syntrophy emerges spontaneously in complex metabolic systems.PLoS computational biology · 2019Article
- Wolbachia pipientis grows in Saccharomyces cerevisiae evoking early death of the host and deregulation of mitochondrial metabolism.MicrobiologyOpen · 2019Article
- The genetic basis for adaptation of model-designed syntrophic co-cultures.PLoS computational biology · 2019Article
- Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities.Life (Basel, Switzerland) · 2019Review
- Synthetic Mutualism and the Intervention Dilemma.Life (Basel, Switzerland) · 2019Review
- Self-Establishing Communities: A Yeast Model to Study the Physiological Impact of Metabolic Cooperation in Eukaryotic Cells.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Hybrid cell reactor system from Escherichia coli protoplast cells and arrayed lipid bilayer chamber device.Scientific reports · 2018Article
- Spatial dynamics of synthetic microbial mutualists and their parasites.PLoS computational biology · 2017Article
- Symbiotic Cell Differentiation and Cooperative Growth in Multicellular Aggregates.PLoS computational biology · 2016Article
- Synthetic transitions: towards a new synthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand how two organisms that have not previously been in contact can establish mutualism, it is first necessary to examine temporal changes in their phenotypes during the establishment of mutualism. Instead of tracing back the history of known, well-established, natural mutualisms, we experimentally simulated the development of mutualism using two genetically-engineered auxotrophic strains of Escherichia coli, which mimic two organisms that have never met before but later establish mutualism. In the development of this synthetic mutualism, one strain, approximately 10 hours after meeting the partner strain, started oversupplying a metabolite essential for the partner's growth, eventually leading to the successive growth of both strains. This cooperative phenotype adaptively appeared only after encountering the partner strain but before the growth of the strain itself. By transcriptome analysis, we found that the cooperative phenotype of the strain was not accompanied by the local activation of the biosynthesis and transport of the oversupplied metabolite but rather by the global activation of anabolic metabolism. This study demonstrates that an organism has the potential to adapt its phenotype after the first encounter with another organism to establish mutualism before its extinction. As diverse organisms inevitably encounter each other in nature, this potential would play an important role in the establishment of a nascent mutualism in nature.
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