ArticlePloS one2011
Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Sequence bias in chromatin fragmentation leads to misinterpretation of protein-DNA interactions in vivo.Genome biology · 2026Article
- Nrm1 is a bistable switch connecting cell cycle progression to transcriptional control.EMBO reports · 2025Article
- Analysis of transcriptional response in haploid and diploid Schizosaccharomyces pombe under genotoxic stress.G3 (Bethesda, Md.) · 2024Article
- Article
- SWI/SNF and RSC remodeler complexes bind to MBF-dependent genes.Cell cycle (Georgetown, Tex.) · 2021Article
- TheBiomolecules · 2021Article
- Characterisation of unessential genes required for survival under conditions of DNA stress.Journal, genetic engineering & biotechnology · 2020Article
- Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.Nucleic acids research · 2019Article
- Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication.Current genetics · 2019Review
- Cell Cycle-Regulated Transcription of CENP-A by the MBF Complex Ensures Optimal Level of CENP-A for Centromere Formation.Genetics · 2019Article
- A novel role for ATR/Rad3 in G1 phase.Scientific reports · 2018Article
- Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.Cell reports · 2017Article
- Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness.PLoS genetics · 2017Article
- Review
- Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.The Journal of biological chemistry · 2016Article
- Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.Scientific reports · 2015Article
- Article
- The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.Molecular biology of the cell · 2013Article
- Control of cell cycle transcription during G1 and S phases.Nature reviews. Molecular cell biology · 2013Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundIn fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase. However, activation of the DNA replication checkpoint response during S phase results in persistent expression of MBF-dependent genes. METHODOLOGY/PRINCIPAL
findingsThis report shows that Yox1p binding to MBF is Nrm1-dependent and that Yox1p and Nrm1p require each other to bind and repress MBF targets. In response to DNA replication stress both Yox1p and Nrm1p dissociate from MBF at promoters leading to de-repression of MBF targets. Inactivation of Yox1p is an essential part of the checkpoint response. Cds1p (human Chk2p) checkpoint protein kinase-dependent phosphorylation of Yox1p promotes its dissociation from the MBF transcription factor. We establish that phosphorylation of Yox1p at Ser114, Thr115 is required for maximal checkpoint-dependent activation of the G1/S cell-cycle transcriptional program. CONCLUSIONS/SIGNIFICANCE: This study shows that checkpoint-dependent phosphorylation of Yox1p at Ser114, Thr115 results in de-repression of the MBF transcriptional program. The remodeling of the cell cycle transcriptional program by the DNA replication checkpoint is likely to comprise an important mechanism for the avoidance of genomic instability.
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