Evidence map›Paper›PMID 21359154›Full record

ArticleDrug discovery today. Disease models2010

Experimental Models of Membranous Nephropathy.

J Ashley Jefferson, Jeffrey W Pippin, Stuart J Shankland

Abstract read
In one paragraph

Article in Drug discovery today. Disease models, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  19. Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Ashley JeffersonDivision of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Jeffrey W Pippin
Stuart J Shankland

Funding

CELL CYCLE PROTEINS AND GLOMERULAR APOPTOSISR01DK056799 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2000 to 2014
$3.6M
CELL CYCLE CONTROL IN GLOMERULAR DISEASER01DK051096 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 1997 to 2007
$1.8M
MECHANISMS OF PODOCYTE INJURYR01DK060525 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART · 2002 to 2005
$1.1M
NIDDK NIH HHS R01 DK051096NIDDK NIH HHS R01 DK056799NIDDK NIH HHS R01 DK060525
6 · The paper itself

Abstract

Membranous nephropathy (MN) is one of the commonest glomerular diseases, typically presenting in older males with nephrotic syndrome. The development and characterization of animal models of MN, in particular, the passive Heymann nephritis model (PHN), has greatly advanced our understanding of this disease. In this review we discuss the different animal models of human MN that are available, with an emphasis on the PHN model, including technical issues, the typical disease course and its application to human disease.

Identifiers

PMID21359154
PMCPMC3042693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.