ArticlePloS one2011
A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Context-Dependent Stability and Robustness of Genetic Toggle Switches with Leaky Promoters.Life (Basel, Switzerland) · 2021Article
- Stability and Robustness of Unbalanced Genetic Toggle Switches in the Presence of Scarce Resources.Life (Basel, Switzerland) · 2021Article
- Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.Cell systems · 2018Article
- Synthesizing genetic sequential logic circuit with clock pulse generator.BMC systems biology · 2014Article
- Systematic design methodology for robust genetic transistors based on I/O specifications via promoter-RBS libraries.BMC systems biology · 2013Article
- The biological microprocessor, or how to build a computer with biological parts.Computational and structural biotechnology journal · 2013Review
- Multicellular computing using conjugation for wiring.PloS one · 2013Article
- A reconfigurable NAND/NOR genetic logic gate.BMC systems biology · 2012Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the design and analysis of a synthetic gene network that performs frequency multiplication. It takes oscillatory transcription factor concentrations, such as those produced from the currently available genetic oscillators, as an input, and produces oscillations with half the input frequency as an output. Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a switch or an oscillator, depending on the temporal nature of the input. Multi-functionality is often observed in neuronal networks, where it is suggested to allow for the efficient coordination of different responses. This network represents a significant theoretical addition that extends the capabilities of synthetic gene networks.
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Registered trials
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