ArticleKorean journal of pediatrics2011
Asthma in childhood: a complex, heterogeneous disease.
Article in Korean journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Exploring the role of cold air in airway hyperresponsiveness and asthma diagnostic testing: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Childhood Asthma Biomarkers Derived from Plasma and Saliva Exosomal miRNAs.International journal of molecular sciences · 2025Article
- eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review.Journal of medical Internet research · 2023Article
- Article
- Early life environmental predictors of asthma age-of-onset.Immunity, inflammation and disease · 2014Article
- Indoor air pollution and respiratory health of children in the developing world.World journal of clinical pediatrics · 2013Review
- Respiratory health status of children from two different air pollution exposure settings of Sri Lanka: a cross-sectional study.American journal of industrial medicine · 2012Article
- Carotenoid intake and asthma prevalence in Thai children.Pediatric reports · 2012Article
- Microbes and asthma: the missing cellular and molecular links.Current opinion in pulmonary medicine · 2012Review
- Anti-inflammatory Potentials of Excretory/Secretory (ES) and Somatic Products ofIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have provided us with important information about the different wheezing phenotypes in young children and about potential mechanisms and risk factors for the development of chronic asthma. The goal of these studies was to provide a better insight into the causes and natural course of childhood asthma. It is well-known that complicated interactions between genes and environmental factors contribute to the development of asthma. Because childhood is a period of rapid growth in both the lungs and the immune system, developmental factors should be considered in the pathogenesis of childhood asthma. The pulmonary system continues to grow and develop until linear growth is completed. Longitudinal studies have reported significant age-related immune development during postnatal early life. These observations suggest that the phenotypes of childhood asthma vary among children and also in an individual child over time. Improved classification of heterogeneous conditions of the disease will help determine novel strategies for primary and secondary prevention and for the development of individualized treatment for childhood asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.