ArticlePloS one2011
Prostate cancer susceptibility Loci identified on chromosome 12 in African Americans.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Downstream Link of Vitamin D Pathway with Inflammation Irrespective of Plasma 25OHD3: Hints from Vitamin D-Binding Protein (DBP) and Receptor (VDR) Gene Polymorphisms.Biomedicines · 2025Article
- Genetic and biological drivers of prostate cancer disparities in Black men.Nature reviews. Urology · 2024Review
- Review of prostate cancer genomic studies in Africa.Frontiers in genetics · 2022Review
- Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency.PLoS genetics · 2021Article
- Article
- Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Review
- Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis.OncoTargets and therapy · 2018Article
- Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11.Prostate cancer · 2015Article
- Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans.Human genetics · 2014Article
- VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.Molecular cancer research : MCR · 2014Article
- Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes.International journal of cancer · 2014Article
- Comprehensive functional annotation of 77 prostate cancer risk loci.PLoS genetics · 2014Article
- Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis.European journal of human genetics : EJHG · 2013Article
- Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona.BMC medical genetics · 2013Article
- Role of calcium, vitamin D, and the extrarenal vitamin D hydroxylases in carcinogenesis.Anti-cancer agents in medicinal chemistry · 2013Review
- Identification of genetic risk associated with prostate cancer using ancestry informative markers.Prostate cancer and prostatic diseases · 2012Article
- Fine-mapping of IL16 gene and prostate cancer risk in African Americans.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and other individuals of African descent. A number of regions across the genome have been associated to PCa, most of them with moderate effects. A few studies have reported chromosomal changes on 12p and 12q that occur during the onset and development of PCa but to date no consistent association of the disease with chromosome 12 polymorphic variation has been identified. In order to unravel genetic risk factors that underlie PCa health disparities we investigated chromosome 12 using ancestry informative markers (AIMs), which allow us to distinguish genomic regions of European or West African origin, and tested them for association with PCa. Additional SNPs were genotyped in those areas where significant signals of association were detected. The strongest signal was discovered at the SNP rs12827748, located upstream of the PAWR gene, a tumor suppressor, which is amply expressed in the prostate. The most frequent allele in Europeans was the risk allele among African Americans. We also examined vitamin D related genes, VDR and CYP27B1, and found a significant association of PCa with the TaqI polymorphism (rs731236) in the former. Although our results warrant further investigation we have uncovered a genetic susceptibility factor for PCa in a likely candidate by means of an approach that takes advantage of the differential contribution of parental groups to an admixed population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.