ArticleCellular & molecular immunology2011
Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis.
Article in Cellular & molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Marginal zone B cells are required for optimal humoral responses to allograft.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance.Cellular & molecular immunology · 2024Article
- A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ectopic lymphoid structures in the aged lacrimal glands.Clinical immunology (Orlando, Fla.) · 2023Article
- The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients.Frontiers in pharmacology · 2023Article
- JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in anFrontiers in immunology · 2023Article
- Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis.Scientific reports · 2021Article
- Neuraminidase Inhibitor Zanamivir Ameliorates Collagen-Induced Arthritis.International journal of molecular sciences · 2021Article
- Thymic B Cells as a New Player in the Type 1 Diabetes Response.Frontiers in immunology · 2021Review
- Marginal zone SIGN-R1Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Innate Lymphocytes in Inflammatory Arthritis.Frontiers in immunology · 2020Review
- Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus.International journal of molecular sciences · 2019Review
- Article
- Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis.Arthritis research & therapy · 2016Article
- Nodal marginal zone B cells in mice: a novel subset with dormant self-reactivity.Scientific reports · 2016Article
- Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis.Cellular & molecular immunology · 2016Article
- Activated mast cells promote differentiation of B cells into effector cells.Scientific reports · 2016Article
- Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis.Cellular & molecular immunology · 2015Article
- Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Antibodies against type II collagen (CII) are essential for development of collagen-induced arthritis (CIA), but how and where the B-cell response to CII is initiated is not fully known. We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization. The CII-reactive B cells were observed in the spleen and recognized as marginal zone (MZ) B cells. After CII immunization, CII-specific B cells expanded rapidly in the spleen, in contrast to the lymph nodes, with the initial response derived from MZ B cells and later by follicular (FO) B cells. This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells. Further, the MZ B cells migrated to the FO areas upon immunization, possibly providing antigen and activating FO T cells and subsequently FO B cells. Thus, around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen, which was dominated by IgG2a- and IgG2b-positive cells. These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization, suggesting an initiating role of MZ B cells in the development of CIA.
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