ArticleNature immunology2011
The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88.
Article in Nature immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Linoleic acid inhibits lipopolysaccharide-induced inflammation by promoting TLR4 regulated autophagy in murine RAW264.7 macrophages.Journal of applied biomedicine · 2024Article
- Regulation of human THP-1 macrophage polarization by Trichinella spiralis.Parasitology research · 2021Article
- Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model.Parasites & vectors · 2020Article
- Cathepsin L3 FromFrontiers in immunology · 2019Article
- Modulation of TLR2 and TLR4 in Macrophages FollowingHelminthologia · 2018Article
- Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice.Parasites & vectors · 2017Article
- Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis.Scientific reports · 2017Article
- Autophagy in sepsis: Degradation into exhaustion?Autophagy · 2016Review
- Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.PLoS pathogens · 2015Article
- Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.Genes and immunity · 2015Article
- Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence.PLoS neglected tropical diseases · 2015Article
- Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88.Journal of virology · 2015Article
- Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats.Journal of neuroinflammation · 2014Article
- Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.Nature reviews. Immunology · 2013Review
- GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism.PloS one · 2013Article
- Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-12.PloS one · 2013Article
- Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14.PloS one · 2013Article
- Review
- PAMPs and DAMPs: signal 0s that spur autophagy and immunity.Immunological reviews · 2012Review
Corrections and comments
- Retraction · 2011-07-19Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Results Not Reproducible ·
- Commented on by
- Retracted
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Sepsis is one of the most challenging health problems worldwide. Here we found that phagocytes from patients with sepsis had considerable upregulation of Toll-like receptor 4 (TLR4) and TLR2; however, shock-inducing inflammatory responses mediated by these TLRs were inhibited by ES-62, an immunomodulator secreted by the filarial nematode Acanthocheilonema viteae. ES-62 subverted TLR4 signaling to block TLR2- and TLR4-driven inflammatory responses via autophagosome-mediated downregulation of the TLR adaptor-transducer MyD88. In vivo, ES-62 protected mice against endotoxic and polymicrobial septic shock by TLR4-mediated induction of autophagy and was protective even when administered after the induction of sepsis. Given that the treatments for septic shock at present are inadequate, the autophagy-dependent mechanism of action by ES-62 might form the basis for urgently needed therapeutic intervention against this life-threatening condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.