ArticleNature structural & molecular biology2011
The prospects for designer single-stranded RNA-binding proteins.
Article in Nature structural & molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- The potential of engineered eukaryotic RNA-binding proteins as molecular tools and therapeutics.Wiley interdisciplinary reviews. RNA · 2020Review
- Regulation of pluripotency and reprogramming by RNA binding proteins.Current topics in developmental biology · 2020Review
- Sequence-specific mRNA (New York, N.Y.) · 2019Article
- Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins.PLoS computational biology · 2019Article
- CRISPR/Cas13a targeting of RNA virus in plants.Plant cell reports · 2018Article
- An engineered RNA binding protein with improved splicing regulation.Nucleic acids research · 2018Article
- Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.Molecular cell · 2017Article
- The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity.Nucleic acids research · 2016Article
- Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins.Nature chemical biology · 2016Article
- C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.Science (New York, N.Y.) · 2016Article
- RNA assemblages orchestrate complex cellular processes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- RNA-binding proteins involved in post-transcriptional regulation in bacteria.Frontiers in microbiology · 2015Review
- Article
- Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNA.Journal of biological engineering · 2014Article
- Amino acid signature enables proteins to recognize modified tRNA.Biochemistry · 2014Article
- Molecular neuroanatomy: a generation of progress.Trends in neurosciences · 2014Review
- Engineering RNA-binding proteins for biology.The FEBS journal · 2013Review
- Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism.The FEBS journal · 2013Review
- New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217.The Journal of biological chemistry · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spectacular progress has been made in the design of proteins that recognize double-stranded DNA with a chosen specificity, to the point that designer DNA-binding proteins can be ordered commercially. This success raises the question of whether it will be possible to engineer libraries of proteins that can recognize RNA with tailored specificity. Given the recent explosion in the number and diversity of RNA species demonstrated to play roles in biology, designer RNA-binding proteins are set to become valuable tools, both in the research laboratory and potentially in the clinic. Here we discuss the prospects for the realization of this idea.
Indexed as
Identifiers
21358629What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.