ArticleJournal of acquired immune deficiency syndromes (1999)2011
Hormonal contraceptive use and HIV disease progression among women in Uganda and Zimbabwe.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Specialized DNA Structures Act as Genomic Beacons for Integration by Evolutionarily Diverse Retroviruses.Viruses · 2023Pooled it
- Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.Nature communications · 2024Article
- Per-pathogen virulence of HIV-1 subtypes A, C and D.Proceedings. Biological sciences · 2023Article
- Evaluation of multi-assay algorithms for cross-sectional HIV incidence estimation in settings with universal antiretroviral treatment.BMC infectious diseases · 2022Article
- Regression with interval-censored covariates: Application to cross-sectional incidence estimation.Biometrics · 2022Article
- An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.Journal of virology · 2021Article
- A top scoring pairs classifier for recent HIV infections.Statistics in medicine · 2021Article
- Comprehensive Profiling of HIV Antibody Evolution.Cell reports · 2019Article
- The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis-Specific Host Immunity Through the Glucocorticoid Receptor.The Journal of infectious diseases · 2019Article
- Identification and validation of a multi-assay algorithm for cross-sectional HIV incidence estimation in populations with subtype C infection.Journal of the International AIDS Society · 2018Article
- Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.PLoS pathogens · 2018Article
- Prevalence and Factors Associated with Contraceptive Use among HIV-Infected Women of Reproductive Age Attending Infectious Disease Clinic at Gulu Regional Referral Hospital, Northern Uganda.BioMed research international · 2018Article
- Pregnancy and HIV Disease Progression in an Early Infection Cohort from Five African Countries.Epidemiology (Cambridge, Mass.) · 2017Article
- Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa.EBioMedicine · 2016Article
- Hormonal Contraception, Pregnancy, Breastfeeding, and Risk of HIV Disease Progression Among Zambian Women.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Associations of hormonal contraceptive use with measures of HIV disease progression and antiretroviral therapy effectiveness.Contraception · 2016Article
- Hormonal Contraception and Risk of Psychiatric and Other Noncommunicable Diseases in HIV-Infected Women.Journal of women's health (2002) · 2015Article
- Comparison of antibody responses to HIV infection in Ugandan women infected with HIV subtypes A and D.AIDS research and human retroviruses · 2015Article
- Immune responses in Ugandan women infected with subtypes A and D HIV using the BED capture immunoassay and an antibody avidity assay.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Hormonal contraceptive use and discontinuation among HIV-infected women in Uganda and Zimbabwe.Journal of acquired immune deficiency syndromes (1999) · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundHIV-infected women need highly effective contraception to reduce unintended pregnancies and mother-to-child HIV transmission. Previous studies report conflicting results regarding the effect of hormonal contraception on HIV disease progression.
methodsHIV-infected women in Uganda and Zimbabwe were recruited immediately after seroconversion; CD4 testing and clinical examinations were conducted quarterly. The study end point was time to AIDS (two successive CD4 200 cells/mm or less or World Health Organization advanced Stage 3 or Stage 4 disease). We used marginal structural Cox survival models to estimate the effect of cumulative exposure to depot-medroxyprogesterone acetate and oral contraceptives on time to AIDS.
resultsThree hundred three HIV-infected women contributed 1408 person-years. One hundred eleven women (37%) developed AIDS. Cumulative probability of AIDS was 50% at 7 years and did not vary by country. AIDS incidence was 6.6, 9.3, and 8.8 per 100 person-years for depot-medroxyprogesterone acetate, oral contraceptive, and nonhormonal users. Neither depot-medroxyprogesterone acetate (adjusted hazard ratio, 0.90; 95% confidence interval, 0.76-1.08) nor oral contraceptives ( adjusted hazard ratio, 1.07; 95% confidence interval, 0.89-1.29) were associated with HIV disease progression. Alternative exposure definitions of hormonal contraception use during the year before AIDS or at the time of HIV infection produced similar results. Sexually transmitted infection symptoms were associated with faster progression, whereas young age at HIV infection (18-24 years) was associated with slower progression. Adding baseline CD4 level and set point viral load to models did not change the hormonal contraception results, but Subtype D infection became associated with disease progression.
conclusionHormonal contraceptive use was not associated with more rapid HIV disease progression, but older age, sexually transmitted infection symptoms, and Subtype D infection were.
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