Evidence map›Paper›PMID 21357890›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2011

Lymphangioleiomyomatosis: what do we know and what are we looking for?

S Harari, O Torre, J Moss

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Sex and gender in interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Ultra-rare cystic disease.European respiratory review : an official journal of the European Respiratory Society · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

S HarariUnità Operativa di Pneumologia e Terapia Semi-Intensiva Respiratoria--Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare Ospedale San Giuseppe, via San Vittore 12, Milan, Italy. sharari@ilpolmone.it
O Torre
J Moss

Funding

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)ZIAHL002541 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MOSS, JOEL · 2009 to 2025
$47.7M
ADP-ribosylation CyclesZIAHL000659 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MOSS, JOEL · 2009 to 2025
$29.8M
Intramural NIH HHS ZIA HL000659Intramural NIH HHS ZIA HL002541
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease characterised by proliferation of abnormal smooth muscle-like cells (LAM cells) leading to progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumours. It affects predominantly females and can occur sporadically or in patients with tuberous sclerosis complex. This review describes the recent progress in our understanding of the molecular pathogenesis of the disease and LAM cell biology. It also summarises current therapeutic approaches and the most promising areas of research for future therapeutic strategies.

Indexed as

Cell ProliferationDiagnosis, DifferentialFemaleGene Expression RegulationHumansLungLymphangioleiomyomatosisMagnetic Resonance ImagingMyocytes, Smooth MusclePredictive Value of TestsRisk FactorsSex FactorsSignal TransductionTomography, X-Ray ComputedTreatment OutcomeTuberous Sclerosis

Identifiers

PMID21357890
PMCPMC3386525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.