ArticleInfection and immunity2011
Transcriptome analysis of avian pathogenic Escherichia coli O1 in chicken serum reveals adaptive responses to systemic infection.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Transcriptional changes related to metabolic and iron acquisition strategies of avian pathogenicFrontiers in cellular and infection microbiology · 2026Article
- RyhB Regulates Capsular Synthesis for Serum Resistance and Virulence of Avian PathogenicInternational journal of molecular sciences · 2025Article
- Molecular detection of avian pathogenicHeliyon · 2024Article
- FdeC expression regulates motility and adhesion of the avian pathogenic Escherichia coli strain IMT5155.Veterinary research · 2024Article
- Pathogenicity and identification of host adaptation genes of the avian pathogenicFrontiers in cellular and infection microbiology · 2024Article
- Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance ofGenes · 2022Article
- Characterization of virulence determinants and phylogenetic background of multiple and extensively drug resistant Escherichia coli isolated from different clinical sources in Egypt.Applied microbiology and biotechnology · 2022Article
- Extraintestinal PathogenicPathogens (Basel, Switzerland) · 2021Review
- Surviving Serum: the Escherichia coliInfection and immunity · 2021Article
- Transcriptomic and Metabolomic Profiling Reveals That KguR Broadly Impacts the Physiology of UropathogenicFrontiers in microbiology · 2021Article
- Transcriptome analysis unveils survival strategies of Streptococcus parauberis against fish serum.PloS one · 2021Article
- Article
- Validation of Predicted Virulence Factors inToxins · 2019Article
- Identification of common highly expressed genes of Salmonella Enteritidis by in silico prediction of gene expression and in vitro transcriptomic analysis.Poultry science · 2019Article
- Messenger RNA Sequencing and Pathway Analysis Provide Novel Insights Into the Susceptibility toFrontiers in genetics · 2018Article
- AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection.Scientific reports · 2016Article
- ArcA Controls Metabolism, Chemotaxis, and Motility Contributing to the Pathogenicity of Avian Pathogenic Escherichia coli.Infection and immunity · 2015Article
- The ssbL gene harbored by the ColV plasmid of an Escherichia coli neonatal meningitis strain is an auxiliary virulence factor boosting the production of siderophores through the shikimate pathway.Journal of bacteriology · 2014Article
- DNA methylome in spleen of avian pathogenic Escherichia coli-challenged broilers and integration with mRNA expression.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections of avian pathogenic Escherichia coli (APEC) result in annual multimillion-dollar losses to the poultry industry. Despite this, little is known about the mechanisms by which APEC survives and grows in the bloodstream. Thus, the aim of this study was to identify molecular mechanisms enabling APEC to survive and grow in this critical host environment. To do so, we compared the transcriptome of APEC O1 during growth in Luria-Bertani broth and chicken serum. Several categories of genes, predicted to contribute to adaptation and growth in the avian host, were identified. These included several known virulence genes and genes involved in adaptive metabolism, protein transport, biosynthesis pathways, stress resistance, and virulence regulation. Several genes with unknown function, which were localized to pathogenicity islands or APEC O1's large virulence plasmid, pAPEC-O1-ColBM, were also identified, suggesting that they too contribute to survival in serum. The significantly upregulated genes dnaK, dnaJ, phoP, and ybtA were subsequently subjected to mutational analysis to confirm their role in conferring a competitive advantage during infection. This genome-wide analysis provides novel insight into processes that are important to the pathogenesis of APEC O1.
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