ArticleGenes & development2011
Autoregulation of convergent RNAi genes in fission yeast.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Post-transcriptional gene silencing triggered by sense transgenes involves uncapped antisense RNA and differs from silencing intentionally triggered by antisense transgenes.Nucleic acids research · 2015Article
- An antisense RNA-mediated mechanism eliminates a meiosis-specific copper-regulated transcript in mitotic cells.The Journal of biological chemistry · 2015Article
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.The EMBO journal · 2014Article
- Article
- RNAi-mediated gene silencing in zebrafish triggered by convergent transcription.Scientific reports · 2014Article
- Article
- 3' Untranslated regions mediate transcriptional interference between convergent genes both locally and ectopically in Saccharomyces cerevisiae.PLoS genetics · 2014Article
- Genome-wide analysis of poly(A) site selection in Schizosaccharomyces pombe.RNA (New York, N.Y.) · 2013Article
- RNAi function, diversity, and loss in the fungal kingdom.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.Nature reviews. Genetics · 2013Review
- Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.Nature structural & molecular biology · 2012Article
- Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation.Nature structural & molecular biology · 2012Article
- Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery.Genes & development · 2012Article
- Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast.Genetics · 2012Article
- Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe.Molecular systems biology · 2011Article
- RNAi genes pave their own way.Genes & development · 2011Article
- Transcriptional regulation at the yeast nuclear envelope.Nucleus (Austin, Tex.)Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
RNAi plays a central role in the regulation of eukaryotic genes. In Schizosaccharomyces pombe fission yeast, RNAi involves the formation of siRNA from dsRNA that acts to establish and maintain heterochromatin over centromeres, telomeres, and mating loci. We showed previously that transient heterochromatin also forms over S. pombe convergent genes (CGs). Remarkably, most RNAi genes are themselves convergent. We demonstrate here that transient heterochromatin formed by the RNAi pathway over RNAi CGs leads to their autoregulation in G1-S. Furthermore, the switching of RNAi gene orientation from convergent to tandem causes loss of their G1-S down-regulation. Surprisingly, yeast mutants with tandemized dcr1, ago1, or clr4 genes display aberrant centromeric heterochromatin, which results in abnormal cell morphology. Our results emphasize the significance of gene orientation for correct RNAi gene expression, and suggest a role for cell cycle-dependent formation of RNAi CG heterochromatin in cellular integrity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.