ArticleGenes & development2011
Subnuclear segregation of genes and core promoter factors in myogenesis.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 92 citations in OpenAlex.
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- Nuclear organization and dynamics: The final Frontier for understanding genome regulation.Frontiers in cell and developmental biology · 2022Article
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- Histone chaperone CAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies.The EMBO journal · 2021Article
- The Plant Nuclear Envelope and Its Role in Gene Transcription.Frontiers in plant science · 2021Review
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.Nature communications · 2020Article
- Lamina-associated domains: peripheral matters and internal affairs.Genome biology · 2020Review
- Local and global chromatin interactions are altered by large genomic deletions associated with human brain development.Nature communications · 2018Article
- A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.Cell reports · 2018Article
- Mechanisms of allelic and clinical heterogeneity of lamin A/C phenotypes.Physiological genomics · 2018Review
- The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.Seminars in cell & developmental biology · 2017Review
- Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex.Developmental cell · 2017Article
- Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.Cell · 2017Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Recent findings implicate alternate core promoter recognition complexes in regulating cellular differentiation. Here we report a spatial segregation of the alternative core factor TAF3, but not canonical TFIID subunits, away from the nuclear periphery, where the key myogenic gene MyoD is preferentially localized in myoblasts. This segregation is correlated with the differential occupancy of TAF3 versus TFIID at the MyoD promoter. Loss of this segregation by modulating either the intranuclear location of the MyoD gene or TAF3 protein leads to altered TAF3 occupancy at the MyoD promoter. Intriguingly, in differentiated myotubes, the MyoD gene is repositioned to the nuclear interior, where TAF3 resides. The specific high-affinity recognition of H3K4Me3 by the TAF3 PHD (plant homeodomain) finger appears to be required for the sequestration of TAF3 to the nuclear interior. We suggest that intranuclear sequestration of core transcription components and their target genes provides an additional mechanism for promoter selectivity during differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.