ArticleGut2011
Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk.
Article in Gut, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis: glutathione S-transferase T1 null allele is associated with gastric cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Risk factors for gastric cancer in Latin America: a meta-analysis.Cancer causes & control : CCC · 2013Pooled it
- Helicobacter pylori iceA, clinical outcomes, and correlation with cagA: a meta-analysis.PloS one · 2012Pooled it
- Effect of treatment failure on the CagA EPIYA motif inWorld journal of gastroenterology · 2017Trial
- Review
- Rethinking gastric carcinogenesis: a multiscale ecological model of risk beyondFrontiers in microbiology · 2026Review
- GrafGen: distance-based inference of population ancestry for Helicobacter pylori genomes.BMC bioinformatics · 2025Article
- Investigation of new Helicobacter pylori variants among cagA positive strains using MLST typing method in Iraq.Scientific reports · 2025Article
- Descriptive epidemiology of gastric cancer in Costa Rica from 1990 to 2022 and projection of deaths to 2050: a population-based study.Lancet regional health. Americas · 2025Article
- UnravelingVaccines · 2025Review
- Resistome and virulome determination inMicrobiology spectrum · 2025Article
- Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics.Microorganisms · 2025Article
- Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis.Methods in enzymology · 2025Article
- Genomic epidemiology ofFrontiers in microbiology · 2025Article
- Targeting hypoxia-inducible factor-1 alpha suppressesGut microbes · 2023Article
- Study ofCancers · 2023Article
- Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development.Current topics in microbiology and immunology · 2023Article
- Recombination events drives the emergence of ColombianVirulence · 2022Article
- Identification of functional tumor necrosis factor-alpha promoter variants associated withWorld journal of gastroenterology · 2022Observational
- Fungal Microbiota Dysbiosis and Ecological Alterations in Gastric Cancer.Frontiers in microbiology · 2022Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
16 authors.
Funding
Abstract
BACKGROUND AND
aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions.
methodsMulti-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry.
resultsWe show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters.
conclusionThe phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.