Evidence map›Paper›PMID 21357505›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2011

Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans.

John J Durocher, Jenna C Klein, Jason R Carter

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
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  4. Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John J DurocherDepartment of Exercise Science, Health and Physical Education, Michigan Technological University, Houghton, Michigan, USA.
Jenna C Klein
Jason R Carter
Michigan Technological University · US

Funding

Sleep deprivation and neurovascular control in humansR21HL098676 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CARTER, JASON R · 2010 to 2011
$426k
Fish oil and neurovascular control in humansR15HL088689 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CARTER, JASON R · 2008 to 2009
$232k
NHLBI NIH HHS HL-088689NHLBI NIH HHS HL-098676
6 · The paper itself

Abstract

Mental stress consistently induces a pressor response that is often accompanied by a paradoxical increase of muscle sympathetic nerve activity (MSNA). The purpose of the present study was to evaluate sympathetic baroreflex sensitivity (BRS) by examining the relations between spontaneous fluctuations of diastolic arterial pressure (DAP) and MSNA. We hypothesized that sympathetic BRS would be attenuated during mental stress. DAP and MSNA were recorded during 5 min of supine baseline, 5 min of mental stress, and 5 min of recovery in 32 young healthy adults. Burst incidence and area were determined for each cardiac cycle and placed into 3-mmHg DAP bins; the slopes between DAP and MSNA provided an index of sympathetic BRS. Correlations between DAP and MSNA were strong (> 0.5) during baseline in 31 of 32 subjects, but we evaluated the change in slope only for those subjects maintaining a strong correlation during mental stress (16 subjects). During baseline, the relation between DAP and MSNA was negative when expressed as either burst incidence [slope = -1.95 ± 0.18 bursts·(100 beats)⁻¹)·mmHg⁻¹; r = -0.86 ± 0.03] or total MSNA [slope = -438 ± 91 units·(beat)⁻¹ mmHg⁻¹; r = -0.76 ± 0.06]. During mental stress, the slope between burst incidence and DAP was significantly reduced [slope = -1.14 ± 0.12 bursts·(100 beats)⁻¹·mmHg⁻¹; r = -0.72 ± 0.03; P < 0.01], indicating attenuation of sympathetic BRS. A more detailed analysis revealed an attenuation of sympathetic BRS during the first 2 min of mental stress (P < 0.01) but no change during the final 3 min of mental stress (P = 0.25). The present study demonstrates that acute mental stress attenuates sympathetic BRS, which may partially contribute to sympathoexcitation during the mental stress-pressor response. However, this attenuation appears to be isolated to the onset of mental stress. Moreover, variable MSNA responses to mental stress do not appear to be directly related to sympathetic BRS.

Indexed as

AdultBaroreflexBlood PressureHeart RateHumansMaleMuscle, SkeletalStress, PsychologicalSympathetic Nervous System

Identifiers

PMID21357505
PMCPMC3094089
OpenAlexW2161076481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.