ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Mild DOCA-salt hypertension: sympathetic system and role of renal nerves.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- The importance of cross-talk in research and the body: An early career researcher perspective.Experimental physiology · 2026Article
- Effects of adrenal ablation on blood pressure and target organ damage in deoxycorticosterone acetate-salt hypertensive rats.The Journal of international medical research · 2026Article
- Preferential renal tubular injury and increased renal sympathetic activity occur during the early stages of DOCA-salt hypertension in male rats.Physiological reports · 2026Article
- Renal denervation for hypertensive heart disease and atrial fibrillation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats.International journal of hypertension · 2024Article
- Physiological ischemic training improves cardiac function through the attenuation of cardiomyocyte apoptosis and the activation of the vagus nerve in chronic heart failure.Frontiers in neuroscience · 2023Article
- Zyxin protects from hypertension-induced cardiac dysfunction.Cellular and molecular life sciences : CMLS · 2022Article
- Patient Selection for Renal Denervation in Hypertensive Patients: What Makes a Good Candidate?Vascular health and risk management · 2022Review
- Left ventricular geometry, tissue composition, and residual stress in High Fat Diet Dahl-Salt sensitive rats.Experimental mechanics · 2021Article
- Excessive dietary salt promotes aortic stiffness in murine renovascular hypertension.American journal of physiology. Heart and circulatory physiology · 2020Article
- Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection.Molecular therapy. Methods & clinical development · 2020Article
- Renal nerves contribute to hypertension in Schlager BPH/2J mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Chronic Blockade of Brain Endothelin Receptor Type-A (ETInternational journal of molecular sciences · 2018Article
- Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation.Frontiers in physiology · 2018Article
- DOCA-Salt Hypertension: an Update.Current hypertension reports · 2017Review
- Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Cerebrospinal Fluid Hypernatremia Elevates Sympathetic Nerve Activity and Blood Pressure via the Rostral Ventrolateral Medulla.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Global- and renal-specific sympathoinhibition in aldosterone hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Role of cardiac sympathetic nerves in blood pressure regulation.Autonomic neuroscience : basic & clinical · 2014Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Excess sympathetic nervous system activity (SNA) is linked to human essential and experimental hypertension. To test whether sympathetic activation is associated with a model of deoxycorticosterone acetate (DOCA)-salt hypertension featuring two kidneys and a moderate elevation of blood pressure, we measured whole body norepinephrine (NE) spillover as an index of global SNA. Studies were conducted in chronically catheterized male Sprague-Dawley rats drinking water containing 1% NaCl and 0.2% KCl. After a 7-day surgical recovery and a 3-day control period, a DOCA pellet (50 mg/kg) was implanted subcutaneously in one group of rats (DOCA), while the other group underwent sham implantation (Sham). NE spillover was measured on control day 2 and days 7 and 14 after DOCA administration or sham implantation. During the control period, mean arterial pressure (MAP) was similar in Sham and DOCA rats. MAP was significantly increased in the DOCA group compared with the Sham group after DOCA administration (day 14: Sham = 109 ± 5.3, DOCA = 128 ± 3.6 mmHg). However, plasma NE concentration, clearance, and spillover were not different in the two groups at any time. To determine whether selective sympathetic activation to the kidneys contributes to hypertension development, additional studies were performed in renal denervated (RDX) and sham-denervated (Sham-DX) rats. MAP, measured by radiotelemetry, was similar in both groups during the control and DOCA treatment periods. In conclusion, global SNA is not increased during the development of mild DOCA-salt hypertension, and fully intact renal nerves are not essential for hypertension development in this model.
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