ArticleThe Plant cell2011
A per-ARNT-sim-like sensor domain uniquely regulates the activity of the homeodomain leucine zipper transcription factor REVOLUTA in Arabidopsis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Genome-wide identification and transcription profiling of safflower (Carthamus tinctorius L.) HD-ZIP gene family under water deficit.BMC genomics · 2025Article
- Domain characteristics, classification and expression profiles in response to various abiotic stresses of four HD-Zip subfamilies in tea plant.BMC plant biology · 2025Article
- ALTERED MERISTEM PROGRAM1 sustains cellular differentiation by limiting HD-ZIP III transcription factor gene expression.Plant physiology · 2024Article
- The Non-JAZ TIFY Protein TIFY8 ofInternational journal of molecular sciences · 2023Article
- Genome-wide identification and systematic analysis of the HD-Zip gene family and its roles in response to pH in Panax ginseng Meyer.BMC plant biology · 2023Article
- Article
- Post-Embryonic Lateral Organ Development and Adaxial-Abaxial Polarity Are Regulated by the Combined Effect ofInternational journal of molecular sciences · 2021Article
- Patterning a Leaf by Establishing Polarities.Frontiers in plant science · 2020Review
- BcpLH organizes a specific subset of microRNAs to form a leafy head in Chinese cabbage (Horticulture research · 2020Article
- GmZPR3d Interacts with GmHD-ZIP III Proteins and Regulates Soybean Root and Nodule Vascular Development.International journal of molecular sciences · 2019Article
- ALTERED MERISTEM PROGRAM1 Restricts Shoot Meristem Proliferation and Regeneration by Limiting HD-ZIP III-Mediated Expression of RAP2.6L.Plant physiology · 2018Article
- Characterization of miR061 and its target genes in grapevine responding to exogenous gibberellic acid.Functional & integrative genomics · 2017Article
- Homeodomain proteins: an update.Chromosoma · 2016Review
- Setting the PAS, the role of circadian PAS domain proteins during environmental adaptation in plants.Frontiers in plant science · 2015Review
- REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis.Development (Cambridge, England) · 2014Article
- Extensive functional pleiotropy of REVOLUTA substantiated through forward genetics.Plant physiology · 2014Article
- Protein change in plant evolution: tracing one thread connecting molecular and phenotypic diversity.Frontiers in plant science · 2013Review
- Establishing a framework for the Ad/abaxial regulatory network of Arabidopsis: ascertaining targets of class III homeodomain leucine zipper and KANADI regulation.The Plant cell · 2013Article
- Argonautes compete for miR165/166 to regulate shoot apical meristem development.Current opinion in plant biology · 2012Review
- Systematic analysis of sequences and expression patterns of drought-responsive members of the HD-Zip gene family in maize.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Class III homeodomain leucine zipper (HD-ZIP III) transcription factors regulate critical developmental programs in plants; these include leaf polarity, polarity along the shoot-root axis, and stem cell specification and proliferation. One of the defining features of HD-ZIP III proteins is the presence of a Per-ARNT-Sim-like (PAS-like) MEKHLA domain at the C terminus. PAS-like domains are known to respond to a variety of chemical and physical stimuli. Here, we provide evidence that the MEKHLA domain acts as a negative regulator of Arabidopsis thaliana HD-ZIP III REVOLUTA activity. Based on experiments in yeast and plants, we propose a model in which the MEKHLA domain inhibits dimerization through a sequence-independent steric masking mechanism. This inhibition is relieved in response to a cellular signal that requires the C terminus of the MEKHLA domain for its perception. Overexpression experiments suggest that this signal is unequally distributed and/or sensed in the plant. Our data show that the function of the REVOLUTA MEKHLA domain differs among other HD-ZIP III family members; this difference may explain the genetic differences that have been observed among family members. This finding, combined with our phylogenetic analysis, suggests that REVOLUTA is the latest type of HD-ZIP III protein to have evolved in land plants.
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