ArticleThe Plant cell2011
The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 138 citations in OpenAlex.
- GhZAT11 triggers wound-activated bud growth by accelerating sugar transport and cell division.Nature plants · 2026Article
- Root Meristem Maintenance Mechanisms are Key to Plant Defense Against Nanoplastics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-wide identification, characterization, and expression profiling of TIFY family members in Panax notoginseng.BMC genomics · 2025Article
- Folate depletion impact on the cell cycle results in restricted primary root growth in Arabidopsis.Plant molecular biology · 2025Article
- Single-cell RNA sequencing of shoot apex reveals the mechanism of cyclin regulating cell division via auxin signaling pathway inFrontiers in plant science · 2025Article
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
- Functional characterization of D-type cyclins involved in cell division in rice.BMC plant biology · 2024Article
- The SIAMESE family of cell-cycle inhibitors in the response of plants to environmental stresses.Frontiers in plant science · 2024Review
- Physiological Control and Genetic Basis of Leaf Curvature and Heading in Brassica rapa L.Journal of advanced research · 2023Review
- Regulation of early seedling establishment and root development in Arabidopsis thaliana by light and carbohydrates.Planta · 2023Article
- GWAS identifies candidate genes controlling adventitious rooting inHorticulture research · 2023Article
- Characterization of the soybean KRP gene family reveals a key role for GmKRP2a in root development.Frontiers in plant science · 2023Article
- Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level.Scientific reports · 2022Article
- MultipleXLab: A high-throughput portable live-imaging root phenotyping platform using deep learning and computer vision.Plant methods · 2022Article
- Deceleration of the cell cycle underpins a switch from proliferative to terminal divisions in plant stomatal lineage.Developmental cell · 2022Article
- Ectopic Expression of PoplarFrontiers in plant science · 2022Article
- Plant CDKs-Driving the Cell Cycle through Climate Change.Plants (Basel, Switzerland) · 2021Review
- Auxin-Regulated Lateral Root Organogenesis.Cold Spring Harbor perspectives in biology · 2021Review
- Lateral Root Initiation and the Analysis of Gene Function Using Genome Editing with CRISPR inGenes · 2021Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
The integration of cell division in root growth and development requires mediation of developmental and physiological signals through regulation of cyclin-dependent kinase activity. Cells within the pericycle form de novo lateral root meristems, and D-type cyclins (CYCD), as regulators of the G₁-to-S phase cell cycle transition, are anticipated to play a role. Here, we show that the D-type cyclin protein CYCD2;1 is nuclear in Arabidopsis thaliana root cells, with the highest concentration in apical and lateral meristems. Loss of CYCD2;1 has a marginal effect on unstimulated lateral root density, but CYCD2;1 is rate-limiting for the response to low levels of exogenous auxin. However, while CYCD2;1 expression requires sucrose, it does not respond to auxin. The protein Inhibitor-Interactor of CDK/Kip Related Protein2 (ICK2/KRP2), which interacts with CYCD2;1, inhibits lateral root formation, and ick2/krp2 mutants show increased lateral root density. ICK2/KRP2 can modulate the nuclear levels of CYCD2;1, and since auxin reduces ICK2/KRP2 protein levels, it affects both activity and cellular distribution of CYCD2;1. Hence, as ICK2/KRP2 levels decrease, the increase in lateral root density depends on CYCD2;1, irrespective of ICK2/CYCD2;1 nuclear localization. We propose that ICK2/KRP2 restrains root ramification by maintaining CYCD2;1 inactive and that this modulates pericycle responses to auxin fluctuations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.