ArticleJournal of bacteriology2011
Role of BacA in lipopolysaccharide synthesis, peptide transport, and nodulation by Rhizobium sp. strain NGR234.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Exploiting peptide chirality and transport to dissect the complex mechanism of action of host peptides on bacteria.PLoS genetics · 2025Article
- Ureolysis-Driven Microbially Induced Carbonate Precipitation by a Facultatively Anaerobic Thermophilic Bacterium Under High-Temperature and Anaerobic Conditions.Microorganisms · 2025Article
- Analysis of a Methanogen and an Actinobacterium Dominating the Thermophilic Microbial Community of an Electromethanogenic Biocathode.Archaea (Vancouver, B.C.) · 2021Article
- Integrated roles of BclA and DD-carboxypeptidase 1 in Bradyrhizobium differentiation within NCR-producing and NCR-lacking root nodules.Scientific reports · 2017Article
- The Very Long Chain Fatty Acid (CFrontiers in microbiology · 2017Article
- Genome wide transcriptional profiling of Herbaspirillum seropedicae SmR1 grown in the presence of naringenin.Frontiers in microbiology · 2015Article
- Genes conferring copper resistance in Sinorhizobium meliloti CCNWSX0020 also promote the growth of Medicago lupulina in copper-contaminated soil.Applied and environmental microbiology · 2014Article
- Replicon-dependent differentiation of symbiosis-related genes in Sinorhizobium strains nodulating Glycine max.Applied and environmental microbiology · 2014Article
- Functional and structural study of the dimeric inner membrane protein SbmA.Journal of bacteriology · 2013Article
- Elucidation of the 3-O-deacylase gene, pagL, required for the removal of primary β-hydroxy fatty acid from the lipid A in the nitrogen-fixing endosymbiont Rhizobium etli CE3.The Journal of biological chemistry · 2013Article
- Article
- The tRNAarg gene and engA are essential genes on the 1.7-Mb pSymB megaplasmid of Sinorhizobium meliloti and were translocated together from the chromosome in an ancestral strain.Journal of bacteriology · 2013Article
- Characterization of nitric oxide-inducing lipid A derived from Mesorhizobium loti lipopolysaccharide.Microbes and environments · 2012Article
- Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis.PLoS biology · 2011Article
- Biochemical characterization of Sinorhizobium meliloti mutants reveals gene products involved in the biosynthesis of the unusual lipid A very long-chain fatty acid.The Journal of biological chemistry · 2011Article
- The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes.PloS one · 2011Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
BacA of Sinorhizobium meliloti plays an essential role in the establishment of nitrogen-fixing symbioses with Medicago plants, where it is involved in peptide import and in the addition of very-long-chain fatty acids (VLCFA) to lipid A of lipopolysaccharide (LPS). We investigated the role of BacA in Rhizobium species strain NGR234 by mutating the bacA gene. In the NGR234 bacA mutant, peptide import was impaired, but no effect on VLCFA addition was observed. More importantly, the symbiotic ability of the mutant was comparable to that of the wild type for a variety of legume species. Concurrently, an acpXL mutant of NGR234 was created and assayed. In rhizobia, AcpXL is a dedicated acyl carrier protein necessary for the addition of VLCFA to lipid A. LPS extracted from the NGR234 mutant lacked VLCFA, and this mutant was severely impaired in the ability to form functional nodules with the majority of legumes tested. Our work demonstrates the importance of VLCFA in the NGR234-legume symbiosis and also shows that the necessity of BacA for bacteroid differentiation is restricted to specific legume-Rhizobium interactions.
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