ArticleEukaryotic cell2011
Conjugated linoleic acid inhibits hyphal growth in Candida albicans by modulating Ras1p cellular levels and downregulating TEC1 expression.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Metabolomic profiling reveals alterations in Candida pathophysiology and host interactions during primary oral candidiasis and following antifungal treatment.Scientific reports · 2026Article
- The Safety of Nebulized Conjugated Linoleic Acid for COVID-19 Respiratory Tract Infections.Cureus · 2025Article
- Genetic susceptibility to recurrent vulvovaginal candidiasis in an African population from Nairobi, Kenya.Scientific reports · 2025Article
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Molecular association ofFrontiers in cellular and infection microbiology · 2023Review
- Valorization of Invasive Plant Extracts against the Bispecies BiofilmAntibiotics (Basel, Switzerland) · 2022Article
- Lifespan Extension ofInternational journal of molecular sciences · 2022Article
- Antibiofilm Activity of Essential Fatty Acids AgainstInfection and drug resistance · 2022Article
- Antibiofilm and antifungal activities of medium-chain fatty acids against Candida albicans via mimicking of the quorum-sensing molecule farnesol.Microbial biotechnology · 2021Article
- Article
- Metabolic Profiling of Candida auris, a Newly-Emerging Multi-Drug Resistant Candida Species, by GC-MS.Molecules (Basel, Switzerland) · 2019Article
- Antifungal Compounds againstBioMed research international · 2017Review
- Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans.Molecular microbiology · 2016Article
- Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability.Antimicrobial agents and chemotherapy · 2014Article
- Arboretum: reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules.Genome research · 2013Article
- A genome-wide transcriptional analysis of morphology determination in Candida albicans.Molecular biology of the cell · 2013Article
- A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.Antimicrobial agents and chemotherapy · 2012Article
- Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi.Fungal genomics & biology · 2012Article
- Identification of cell cycle-regulated, putative hyphal genes in Candida albicans.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2012Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polymorphic yeast Candida albicans exists in yeast and filamentous forms. Given that the morphogenetic switch coincides with the expression of many virulence factors, the yeast-to-hypha transition constitutes an attractive target for the development of new antifungal agents. Since an untapped therapeutic potential resides in small molecules that hinder C. albicans filamentation, we characterized the inhibitory effect of conjugated linoleic acid (CLA) on hyphal growth and addressed its mechanism of action. CLA inhibited hyphal growth in a dose-dependent fashion in both liquid and solid hypha-inducing media. The fatty acid blocked germ tube formation without affecting cellular growth rates. Global transcriptional profiling revealed that CLA downregulated the expression of hypha-specific genes and abrogated the induction of several regulators of hyphal growth, including TEC1, UME6, RFG1, and RAS1. However, neither UME6 nor RFG1 was necessary for CLA-mediated hyphal growth inhibition. Expression analysis showed that the downregulation of TEC1 expression levels by CLA depended on RAS1. In addition, while RAS1 transcript levels remained constant in CLA-treated cells, its protein levels declined with time. With the use of a strain expressing GFP-Ras1p, CLA treatment was also shown to affect Ras1p localization to the plasma membrane. These findings suggest that CLA inhibits hyphal growth by affecting the cellular localization of Ras1p and blocking the increase in RAS1 mRNA and protein levels. Combined, these effects should prevent the induction of the Ras1p signaling pathway. This study provides the biological and molecular explanations that underlie CLA's ability to inhibit hyphal growth in C. albicans.
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