ArticleInvestigative ophthalmology & visual science2011
The role of the iris in chick accommodation.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Administration of Nicotine Can Inhibit Myopic Growth in Animal Models.Investigative ophthalmology & visual science · 2024Article
- Daily or Less Frequent Topical 1% Atropine Slows Defocus-Induced Myopia Progression in Contact Lens-Wearing Guinea Pigs.Translational vision science & technology · 2022Article
- Visually guided chick ocular length and structural thickness variations assessed by swept-source optical coherence tomography.Biomedical optics express · 2021Article
- Article
- A Comparison of Applanation and Rebound Tonometers in Young Chicks.Current eye research · 2021Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
- Circadian rhythms, refractive development, and myopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2018Review
- The chick eye in vision research: An excellent model for the study of ocular disease.Progress in retinal and eye research · 2017Review
- Pharmacologically stimulated pupil and accommodative changes in Guinea pigs.Investigative ophthalmology & visual science · 2014Article
- Animal modeling for myopia.Advances in ophthalmology practice and researchReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposePeripheral defocus, higher-order aberrations, and accommodation interact with pupil size to influence retinal image quality and possibly eye growth. Iridectomy (ID) provides a fixed, enlarged pupil. Results from in vitro studies suggest that ID may reduce or eliminate accommodation in the chicken. This paper further investigates the effects of ID on chicken accommodation, eye growth, and refractive development.
methodsRefraction, biometry, and corneal curvature were measured, before, and after topical instillation of nicotine in 43 White-Leghorn chickens that had undergone monocular ID. Intraocular pressure (IOP) was measured, and eyes were imaged with anterior segment optical coherence tomography (OCT) during accommodation. In vitro preparations were used to examine accommodation responses in a lens-scanning instrument.
resultsIridectomy induced small but significant decreases in anterior and vitreous chamber depths and an increase in lens thickness (LT). IOP was similar in iridectomized and control eyes from 1 week on. In vivo, nicotine induced similar accommodative changes in iridectomized and control eyes. OCT images revealed a forward displacement of the iris during accommodation in control eyes. Iridectomized and control eyes showed similar increases in LT. In vitro, iridectomized eyes showed minimal nicotine-induced accommodation.
conclusionsRefraction and eye growth were minimally affected by ID in chickens, implying that emmetropization was unaffected and supporting the use of ID as a tool in emmetropization and myopia studies. The greatly attenuated accommodative responses in vitro for iridectomized eyes suggest a role of biomechanical factors in the chick. IOP was unaffected by the surgery, implying that the iris musculature is not essential for maintaining aqueous outflow pathways.
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