ArticleToxicological sciences : an official journal of the Society of Toxicology2011
Arsenic alters ATP-dependent Ca²+ signaling in human airway epithelial cell wound response.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Cellular and molecular roles of reactive oxygen species in wound healing.Communications biology · 2024Review
- Assessment of disease burden in the arsenic exposed population of Chapar village of Samastipur district, Bihar, India, and related mitigation initiative.Environmental science and pollution research international · 2022Article
- State of the science review of the health effects of inorganic arsenic: Perspectives for future research.Environmental toxicology · 2019Review
- Cerium dioxide (CeOEnvironmental research · 2018Article
- In vitro assessment of arsenic mobility in historical mine waste dust using simulated lung fluid.Environmental geochemistry and health · 2018Article
- In vivo and in vitro methods for evaluating soil arsenic bioavailability: relevant to human health risk assessment.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Review
- Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice.Environmental health perspectives · 2017Article
- Plasma membrane wounding and repair in pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine.Respiratory research · 2016Article
- Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex.Current environmental health reports · 2016Review
- The Epithelial Sodium Channel and the Processes of Wound Healing.BioMed research international · 2016Review
- Damage response involves mechanisms conserved across plants, animals and fungi.Current genetics · 2015Review
- Physiological impact of abnormal lipoxin A₄ production on cystic fibrosis airway epithelium and therapeutic potential.BioMed research international · 2015Review
- Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo.Respiratory research · 2014Article
- Extracellular ATP activates MAPK and ROS signaling during injury response in the fungus Trichoderma atroviride.Frontiers in plant science · 2014Article
- Arsenic immunotoxicity: a review.Environmental health : a global access science source · 2013Review
- Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Arsenic is a natural metalloid toxicant that is associated with occupational inhalation injury and contaminates drinking water worldwide. Both inhalation of arsenic and consumption of arsenic-tainted water are correlated with malignant and nonmalignant lung diseases. Despite strong links between arsenic and respiratory illness, underlying cell responses to arsenic remain unclear. We hypothesized that arsenic may elicit some of its detrimental effects on the airway through limitation of innate immune function and, specifically, through alteration of paracrine ATP (purinergic) Ca²+ signaling in the airway epithelium. We examined the effects of acute (24 h) exposure with environmentally relevant levels of arsenic (i.e., < 4 μM as Na-arsenite) on wound-induced Ca²+ signaling pathways in human bronchial epithelial cell line (16HBE14o-). We found that arsenic reduces purinergic Ca²+ signaling in a dose-dependent manner and results in a reshaping of the Ca²+ signaling response to localized wounds. We next examined arsenic effects on two purinergic receptor types: the metabotropic P2Y and ionotropic P2X receptors. Arsenic inhibited both P2Y- and P2X-mediated Ca²+ signaling responses to ATP. Both inhaled and ingested arsenic can rapidly reach the airway epithelium where purinergic signaling is essential in innate immune functions (e.g., ciliary beat, salt and water transport, bactericide production, and wound repair). Arsenic-induced compromise of such airway defense mechanisms may be an underlying contributor to chronic lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.