ArticleToxicological sciences : an official journal of the Society of Toxicology2011
Polymorphisms in the TNF-α and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Association between urinary arsenic concentration and genetic polymorphisms in Korean adults.Toxicological research · 2024Article
- Arsenic Activates the NLRP3 Inflammasome and Disturbs the Th1/Th2/Th17/Treg Balance in the Hippocampus in Mice.Biological trace element research · 2023Article
- Prediction of Hazardous Effect of Heavy Metals of Point-Source Wastewater on Fish (Anabas cobojius) and Human Health.Biological trace element research · 2023Article
- Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR).International journal of environmental research and public health · 2022Article
- Genetic Diversity of Human Host Genes Involved in Immune Response and the Binding of Malaria Parasite in Patients Residing along the Thai-Myanmar border.Tropical medicine and infectious disease · 2021Article
- MicroRNAs play an important role in contributing to arsenic susceptibility in the chronically exposed individuals of West Bengal, India.Environmental science and pollution research international · 2019Article
- Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Seasonal variation of heavy metals in water and sediments in the Halda River, Chittagong, Bangladesh.Environmental science and pollution research international · 2017Article
- Genetic susceptibility to arsenic-induced skin lesions and health effects: a review.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2015Review
- Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice.SpringerPlus · 2015Article
- Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway.International journal of molecular sciences · 2014Article
- Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice.BMC complementary and alternative medicine · 2013Article
- Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India.BMC public health · 2012Article
- Arsenite activates NFκB through induction of C-reactive protein.Toxicology and applied pharmacology · 2012Article
- A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure.Annals of global healthReview
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
In West Bengal, India, at present, more than 26 million people are exposed to arsenic through drinking water. Among them, only 15-20% manifest arsenic-induced noncancerous, precancerous, and cancerous skin lesions, indicating that genetic variants play important role in arsenic susceptibility. Chronic arsenic exposure has been associated with impairment of immune systems in the exposed individuals. Because cytokines are important immune mediators, alteration in expression of these gene products may lead to arsenic-specific disease manifestations. The aim of the present work was to investigate the association between the TNF-α-308G>A (rs1800629) and IL10 -3575T>A (rs1800890) polymorphisms and arsenic-induced dermatological and nondermatological health outcomes. A case-control study was conducted in West Bengal, India, involving 207 cases with arsenic-induced skin lesions and 190 controls without skin lesions having similar arsenic exposure. The polymorphisms were determined using conventional PCR-sequencing method. ELISA was done to determine the serum levels of the two cytokines tumor necrosis factor α (TNF-α) and interleukin 10 (IL10). Associations between the polymorphisms studied and nondermatological health effects in the study subjects were determined from our epidemiological survey data. Individuals with GA/AA (-308 TNF-α) and TA/AA (-3575 IL10) genotypes were at higher risk of developing arsenic-induced skin lesions, ocular, and respiratory diseases. Also the -308 TNF A allele corresponded to a higher production of TNF-α, and -3575 IL10 A allele corresponded to a lower production of IL10. Thus, the polymorphisms studied impart significant risk toward development of arsenic-induced dermatological and nondermatological health effects in the chronically exposed population of West Bengal, India.
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