Evidence map›Paper›PMID 21357377›Full record

Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011

No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer.

Geyu Liang, Abrar A Qureshi, Qun Guo, Immaculata De Vivo, Jiali Han

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2019
    Review
  5. Article
  6. Article
  7. Telomerase promoter mutations in cancer: an emerging molecular biomarker?Virchows Archiv : an international journal of pathology · 2014
    Review
  8. Telomere length varies by DNA extraction method: implications for epidemiologic research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Geyu LiangDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Abrar A Qureshi
Qun Guo
Immaculata De Vivo
Jiali Han

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
BIOCHEMICAL MARKERS IN THE NURSES HEALTH STUDY COHORTU01CA049449 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HANKINSON, SUSAN E · 1995 to 2013
$5.4M
Molecular signatures of melanoma histology and progression: A Population Based AR01CA137365 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI QURESHI, ABRAR A · 2009 to 2013
$1.4M
Prospective study of telomere length and melanoma riskR03CA133914 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAN, JIALI · 2008 to 2009
$175k
NCI NIH HHS CA055075NCI NIH HHS CA133914NCI NIH HHS CA49449NCI NIH HHS CA87969NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA137365NCI NIH HHS R03 CA133914NCI NIH HHS U01 CA049449
6 · The paper itself

Abstract

backgroundRecent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent.

methodsWe prospectively evaluated the association of telomere length in peripheral blood leukocytes with the risk of skin squamous cell carcinoma (SCC) in 241 cases and 241 controls within the Health Professionals Follow-up Study (HPFS), and the risk of skin basal cell carcinoma (BCC) in 623 cases and 1,943 controls within the Nurses' Health Study (NHS).

resultsNo significant association was observed between telomere length and risk of SCC (longest quartile vs. shortest quartile, OR = 1.09, 95%CI: 0.62-1.93, P = 0.81). Null findings were also observed between telomere length and risk of BCC in 2 independent sets (OR = 0.96, 95%CI: 0.49-1.87, P = 0.83; and OR = 0.91, 95%CI: 0.66-1.25, P = 0.39).

conclusionWe found no evidence that telomere length in peripheral blood leukocytes was associated with risk of nonmelanoma skin cancer. IMPACT: Our prospective study suggests that telomere length in peripheral blood leukocytes is less likely to play a substantial role in nonmelanoma skin cancer development.

Indexed as

AdultAgedBasal Cell CarcinomaCarcinoma, Squamous CellCase-Control StudiesCohort StudiesDNA, NeoplasmFollow-Up StudiesHumansLeukocytesMaleMiddle AgedNursesPolymerase Chain ReactionPrognosisProspective StudiesDNA, Neoplasm

Identifiers

PMID21357377
PMCPMC3089713

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.