ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of cellular aging on memory T-cell homeostasis.Frontiers in immunology · 2022Article
- Different recovery patterns of CMV-specific and WT1-specific T cells in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: Impact of CMV infection and leukemia relapse.Frontiers in immunology · 2022Article
- A New Method Based on the von Mises-Fisher Distribution Shows that a Minority of Liver-Localized CD8 T Cells Display Hard-To-Detect Attraction toFrontiers in bioinformatics · 2021Article
- You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria.Trends in parasitology · 2020Review
- Article
- Nonspecific CD8Infection and immunity · 2018Article
- Heterologous Immunity and Persistent Murine Cytomegalovirus Infection.Journal of virology · 2017Article
- Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Influence of time and number of antigen encounters on memory CD8 T cell development.Immunologic research · 2014Review
- CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model.Frontiers in microbiology · 2014Review
- CD8Current immunology reviews · 2013Article
- Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans.The Journal of experimental medicine · 2012Article
- Type 1 interferons and antiviral CD8 T-cell responses.PLoS pathogens · 2012Review
- Relevance of long-lived CD8(+) T effector memory cells for protective immunity elicited by heterologous prime-boost vaccination.Frontiers in immunology · 2012Article
- Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells. However, infections with unrelated pathogens, as may occur in areas endemic to malaria, can dramatically decrease pre-existing memory CD8 T cells. It remains unknown whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells and thus limit the duration of antimalarial immunity generated by subunit vaccination. We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent significant attrition in numbers in mice subjected to unrelated infections. Attrition was associated with preferential loss of effector memory CD8 T cells and reduced immunity to P. berghei sporozoite challenge. However, and of relevance to deployment of Plasmodium vaccines in areas endemic to malaria, attrition of memory CD8 T cells was reversed by booster immunization, which restored protection. These data suggest that regular booster immunizations may be required to sustain protective vaccine-induced Plasmodium-specific memory CD8 T cells in the face of attrition caused by unrelated infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.