ReviewSeminars in radiation oncology2011
Functional and molecular image guidance in radiotherapy treatment planning optimization.
Review in Seminars in radiation oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation.Physics in medicine and biology · 2022Article
- HyperpolarizedInternational journal of radiation oncology, biology, physics · 2021Article
- Multiple Testing, Cut-Point Optimization, and Signs of Publication Bias in Prognostic FDG-PET Imaging Studies of Head and Neck and Lung Cancer: A Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2020Review
- A sparse orthogonal collimator for small animal intensity-modulated radiation therapy. Part II: hardware development and commissioning.Medical physics · 2019Article
- Impact of different biologically-adapted radiotherapy strategies on tumor control evaluated with a tumor response model.PloS one · 2018Article
- Patterns-of-failure guided biological target volume definition for head and neck cancer patients: FDG-PET and dosimetric analysis of dose escalation candidate subregions.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2017Article
- Functional lung avoidance and response-adaptive escalation (FLARE) RT: Multimodality plan dosimetry of a precision radiation oncology strategy.Medical physics · 2017Article
- Estimating oxygen distribution from vasculature in three-dimensional tumour tissue.Journal of the Royal Society, Interface · 2016Article
- Oxygen consumption dynamics in steady-state tumour models.Royal Society open science · 2014Article
- A method for estimating the oxygen consumption rate in multicellular tumour spheroids.Journal of the Royal Society, Interface · 2014Article
- Priority-driven plan optimization in locally advanced lung patients based on perfusion SPECT imaging.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Functional and molecular imaging techniques are increasingly being developed and used to quantitatively map the spatial distribution of parameters, such as metabolism, proliferation, hypoxia, perfusion, and ventilation, onto anatomically imaged normal organs and tumor. In radiotherapy optimization, these imaging modalities offer the promise of increased dose sparing to high-functioning subregions of normal organs or dose escalation to selected subregions of the tumor as well as the potential to adapt radiotherapy to functional changes that occur during the course of treatment. The practical use of functional/molecular imaging in radiotherapy optimization must take into cautious consideration several factors whose influences are still not clearly quantified or well understood including patient positioning differences between the planning computed tomography and functional/molecular imaging sessions, image reconstruction parameters and techniques, image registration, target/normal organ functional segmentation, the relationship governing the dose escalation/sparing warranted by the functional/molecular image intensity map, and radiotherapy-induced changes in the image intensity map over the course of treatment. The clinical benefit of functional/molecular image guidance in the form of improved local control or decreased normal organ toxicity has yet to be shown and awaits prospective clinical trials addressing this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.