ArticleThe American journal of pathology2011
Albuminuria and glomerular damage in mice lacking the metabotropic glutamate receptor 1.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Vesicular Glutamate Transporter 3 Is Involved in Glutamatergic Signalling in Podocytes.International journal of molecular sciences · 2025Article
- Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.The EMBO journal · 2023Article
- Ion channels and channelopathies in glomeruli.Physiological reviews · 2023Review
- Urinary mRNA Expression of Glomerular Podocyte Markers in Glomerular Disease and Renal Transplant.Diagnostics (Basel, Switzerland) · 2021Article
- Expression of Glutamate Receptor Subtype 3 Is Epigenetically Regulated in Podocytes under Diabetic Conditions.Kidney diseases (Basel, Switzerland) · 2019Article
- Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina.Neurochemical research · 2016Article
- Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review.Journal of biomedical science · 2015Review
- BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization.The Journal of pathology · 2015Article
- Podocyte developmental defects caused by adriamycin in zebrafish embryos and larvae: a novel model of glomerular damage.PloS one · 2014Article
- Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study.Drug design, development and therapy · 2013Article
- Article
- Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death.Molecular pharmacology · 2012Article
- An association study of the genetic polymorphisms in 13 neural plasticity-related genes with semantic and episodic memories.Journal of molecular neuroscience : MN · 2012Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabotropic glutamate (mGlu) receptor 1 (GRM1) has been shown to play an important role in neuronal cells by triggering, through calcium release from intracellular stores, various signaling pathways that finally modulate neuron excitability, synaptic plasticity, and mechanisms of feedback regulation of neurotransmitter release. Herein, we show that Grm1 is expressed in glomerular podocytes and that a glomerular phenotype is exhibited by Grm1(crv4) mice carrying a spontaneous recessive inactivating mutation of the gene. Homozygous Grm1(crv4/crv4) and, to a lesser extent, heterozygous mice show albuminuria, podocyte foot process effacement, and reduced levels of nephrin and other proteins known to contribute to the maintenance of podocyte cell structure. Overall, the present data extend the role of mGlu1 receptor to the glomerular filtration barrier. The regulatory action of mGlu1 receptor in dendritic spine morphology and in the control of glutamate release is well acknowledged in neuronal cells. Analogously, we speculate that mGlu1 receptor may regulate foot process morphology and intercellular signaling in the podocyte.
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Registered trials
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