ArticleThe American journal of pathology2011
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Fibrinogen superfamily proteins: Key regulators in hepatic disorders.World journal of experimental medicine · 2025Review
- Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver.Blood · 2025Article
- S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.International journal of molecular sciences · 2022Article
- Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice.Toxicology · 2021Article
- Biological Properties of a Citral-Enriched Fraction ofFoods (Basel, Switzerland) · 2020Article
- Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids.Gene expression · 2019Review
- Review
- Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation.International journal of molecular medicine · 2018Article
- Role of the blood coagulation cascade in hepatic fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis.American journal of translational research · 2018Article
- Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters.Frontiers in pharmacology · 2018Article
- Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases.Research and practice in thrombosis and haemostasis · 2017Review
- Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis.Toxicology · 2017Article
- Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis.Journal of biochemical and molecular toxicology · 2017Article
- Role of hemostatic factors in hepatic injury and disease: animal models de-liver.Journal of thrombosis and haemostasis : JTH · 2016Review
- Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.Blood · 2016Article
- Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?Seminars in thrombosis and hemostasis · 2016Review
- Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.Journal of thrombosis and haemostasis : JTH · 2015Article
- Association between plasma fibrinogen levels and mortality in acute-on-chronic hepatitis B liver failure.Disease markers · 2015Article
- Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic cholestatic liver injury induced by cholestasis in rodents is associated with hepatic fibrin deposition, and we found evidence of fibrin deposition in livers of patients with cholestasis. Key components of the fibrinolytic pathway modulate cholestatic liver injury by regulating activation of hepatocyte growth factor. However, the exact role of hepatic fibrin deposition in chronic cholestasis is not known. We tested the hypothesis that fibrinogen (Fbg) deficiency worsens liver injury induced by cholestasis. Fbg-deficient mice (Fbgα(-/-) mice) and heterozygous control mice (Fbgα(+/-) mice) were fed either the control diet or a diet containing 0.025% α-naphthylisothiocyanate (ANIT), which selectively injures bile duct epithelial cells in the liver, for 2 weeks. Hepatic fibrin and collagen deposits were evident in livers of heterozygous control mice fed the ANIT diet. Complete Fbg deficiency was associated with elevated serum bile acids, periportal necrosis, and increased serum alanine aminotransferase activity in mice fed the ANIT diet. Fbg deficiency was associated with enhanced hepatic expression of the transcription factor early growth response-1 (Egr-1) and enhanced induction of genes encoding the Egr-1-regulated proinflammatory chemokines monocyte chemotactic protein-1, KC growth-regulated protein, and macrophage inflammatory protein-2. Interestingly, peribiliary collagen deposition was not evident near necrotic areas in Fbg-deficient mice. The results suggest that in this model of chronic cholestasis, fibrin constrains the release of bile constituents from injured intrahepatic bile ducts, thereby limiting the progression of hepatic inflammation and hepatocellular injury.
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