Evidence map›Paper›PMID 21356275›Full record

ReviewNeuroscience letters2011

Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities.

Shawn McClelland, Céline M Dubé, Jaqueline Yang, Tallie Z Baram

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. NaInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. [Influence of coronavirus disease 2019 on the nervous system of children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Review
  13. Review
  14. Article
  15. Article
  16. The Epilepsy Spectrum: Targeting Future Research Challenges.Cold Spring Harbor perspectives in medicine · 2016
    Review
  17. Article
  18. Article
  19. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  20. Seizures and epilepsy: an overview for neuroscientists.Cold Spring Harbor perspectives in medicine · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shawn McClellandDepartment of Anatomy/Neurobiology, University of California, Irvine, CA 92697-4475, USA.
Céline M Dubé
Jaqueline Yang
Tallie Z Baram
University of California, Irvine · US

Funding

Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
FEBRILE SEIZURE MODEL--NEURONAL INJURY AND MECHANISMSR01NS035439 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 1997 to 2018
$3.2M
Febrile Seizure Model - Neuronal Injury and MechanismsR37NS035439 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2006 to 2012
$2.6M
NINDS NIH HHS R01 NS035439NINDS NIH HHS R37 NS035439NINDS NIH HHS R37NS35439NINDS NIH HHS T32 NS045540NINDS NIH HHS T32NS045540
6 · The paper itself

Abstract

Epidemiological and recent prospective analyses of long febrile seizures (FS) and febrile status epilepticus (FSE) support the idea that in some children, such seizures can provoke temporal lobe epilepsy (TLE). Because of the high prevalence of these seizures, if epilepsy was to arise as their direct consequence, this would constitute a significant clinical problem. Here we discuss these issues, and describe the use of animal models of prolonged FS and of FSE to address the following questions: Are long FS epileptogenic? What governs this epileptogenesis? What are the mechanisms? Are there any predictive biomarkers of the epileptogenic process, and can these be utilized, together with information about the mechanisms of epileptogenesis, for eventual prevention of the TLE that results from long FS and FSE.

Indexed as

AnimalsBiomarkersBrainHumansSeizuresSeizures, FebrileBiomarkers

Identifiers

PMID21356275
PMCPMC3109205
OpenAlexW2071703460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.