ArticleBMC genomics2011
A proteomics approach to decipher the molecular nature of planarian stem cells.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease.Frontiers in cell and developmental biology · 2024Review
- Molecular insights into the heat shock proteins of the human parasitic blood fluke Schistosoma mansoni.Parasites & vectors · 2022Article
- Article
- Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.EMBO reports · 2021Article
- RNAi Screen of RING/U-Box Domain Ubiquitin Ligases Identifies Critical Regulators of Tissue Regeneration in Planarians.Frontiers in cell and developmental biology · 2021Article
- Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarianThe Journal of biological chemistry · 2019Article
- Role of neoblasts in the patterned postembryonic growth of the platyhelminthNeurogenesis (Austin, Tex.) · 2018Article
- Planarian finds time(less) to fight infection.Virulence · 2017Article
- Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea.The Journal of biological chemistry · 2016Article
- Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea.BMC genomics · 2015Article
- Protein expression profiling in head fragments during planarian regeneration after amputation.Development genes and evolution · 2015Article
- iTRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians.PloS one · 2015Article
- Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms.Molecular & cellular proteomics : MCP · 2012Article
- Review
- Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNAseq, RNA interference and irradiation approach.Genome biology · 2012Article
- Transcriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea.PloS one · 2012Article
- The history and enduring contributions of planarians to the study of animal regeneration.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, planaria have emerged as an important model system for research into stem cells and regeneration. Attention is focused on their unique stem cells, the neoblasts, which can differentiate into any cell type present in the adult organism. Sequencing of the Schmidtea mediterranea genome and some expressed sequence tag projects have generated extensive data on the genetic profile of these cells. However, little information is available on their protein dynamics.
resultsWe developed a proteomic strategy to identify neoblast-specific proteins. Here we describe the method and discuss the results in comparison to the genomic high-throughput analyses carried out in planaria and to proteomic studies using other stem cell systems. We also show functional data for some of the candidate genes selected in our proteomic approach.
conclusionsWe have developed an accurate and reliable mass-spectra-based proteomics approach to complement previous genomic studies and to further achieve a more accurate understanding and description of the molecular and cellular processes related to the neoblasts.
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