ArticleBMC genomics2011
Gene expression throughout a vertebrate's embryogenesis.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Cloning, characterization, and spatio-temporal expression patterns of HdhSPARC and its responses to multiple stressors.Scientific reports · 2024Article
- Without a pinch of salt: effect of low salinity on eggs and nauplii of the salmon louse (Lepeophtheirus salmonis).Parasitology research · 2023Article
- Cardiac physiology and metabolic gene expression during late organogenesis among F. heteroclitus embryo families from crosses between pollution-sensitive and -resistant parents.BMC ecology and evolution · 2022Article
- PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression.PloS one · 2021Article
- Time matters! Developmental shift in gene expression between the head and the trunk region of the cichlid fish Astatotilapia burtoni.BMC genomics · 2019Article
- Evolutionary toxicology in an omics world.Evolutionary applications · 2017Article
- Expression Patterns of Atlantic Sturgeon (G3 (Bethesda, Md.) · 2017Article
- Chicken rRNA Gene Cluster Structure.PloS one · 2016Article
- The developmental transcriptome of contrasting Arctic charr (F1000Research · 2015Article
- Global transcriptome analysis identifies regulated transcripts and pathways activated during oogenesis and early embryogenesis in Atlantic cod.Molecular reproduction and development · 2014Article
- Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences.BMC genomics · 2013Article
- Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus).Ecotoxicology (London, England) · 2013Article
- A comparative analysis of transcription factor expression during metazoan embryonic development.PloS one · 2013Article
- A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos.PloS one · 2013Article
- Transcriptomic characterization of the larval stage in gilthead seabream (Sparus aurata) by 454 pyrosequencing.Marine biotechnology (New York, N.Y.) · 2012Article
- Gene expression profiling of Atlantic cod (Gadus morhua) embryogenesis using microarray.Marine biotechnology (New York, N.Y.) · 2012Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDescribing the patterns of gene expression during embryonic development has broadened our understanding of the processes and patterns that define morphogenesis. Yet gene expression patterns have not been described throughout vertebrate embryogenesis. This study presents statistical analyses of gene expression during all 40 developmental stages in the teleost Fundulus heteroclitus using four biological replicates per stage.
resultsPatterns of gene expression for 7,000 genes appear to be important as they recapitulate developmental timing. Among the 45% of genes with significant expression differences between pairs of temporally adjacent stages, significant differences in gene expression vary from as few as five to more than 660. Five adjacent stages have disproportionately more significant changes in gene expression (> 200 genes) relative to other stages: four to eight and eight to sixteen cell stages, onset of circulation, pre and post-hatch, and during complete yolk absorption. The fewest differences among adjacent stages occur during gastrulation. Yet, at stage 16, (pre-mid-gastrulation) the largest number of genes has peak expression. This stage has an over representation of genes in oxidative respiration and protein expression (ribosomes, translational genes and proteases). Unexpectedly, among all ribosomal genes, both strong positive and negative correlations occur. Similar correlated patterns of expression occur among all significant genes.
conclusionsThese data provide statistical support for the temporal dynamics of developmental gene expression during all stages of vertebrate development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.