ArticleBMC complementary and alternative medicine2011
Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Lacticaseibacillus Paracasei Regulates Vaginal Microecology and Inhibits Hyphae Formation for Candida Vaginitis Therapy.Probiotics and antimicrobial proteins · 2026Article
- Untargeted metabolomics uncovers prime pathways linked to antibacterial action of citral against bacterial vaginosis-causingHeliyon · 2024Article
- Overview of Ethnobotanical-Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential.Pharmaceutics · 2024Review
- Quantification methods ofMicrobial cell (Graz, Austria) · 2024Article
- Exploring Plants with Flowers: From Therapeutic Nutritional Benefits to Innovative Sustainable Uses.Foods (Basel, Switzerland) · 2023Review
- Chemical Composition and Anti-Molecules (Basel, Switzerland) · 2023Article
- Synthetic bacterial consortia transplantation for the treatment of Gardnerella vaginalis-induced bacterial vaginosis in mice.Microbiome · 2023Article
- Synergistic effects of carvacrol, α-terpinene, γ-terpinene, ρ-cymene and linalool against Gardnerella species.Scientific reports · 2022Article
- Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis.Infection and drug resistance · 2021Article
- Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections.Veterinary sciences · 2020Review
- Assaying the effect of yeasts on growth of fungi associated with disease.BMC microbiology · 2020Article
- Phytochemical Composition and In Vitro Antimicrobial Activity of Essential Oils from theAntibiotics (Basel, Switzerland) · 2020Article
- Anti-Antibiotics (Basel, Switzerland) · 2020Review
- Essential Oils of Lamiaceae Family Plants as Antifungals.Biomolecules · 2020Review
- Improved in vitro and in vivo Anti-International journal of nanomedicine · 2020Article
- The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice.Scientific reports · 2019Article
- Antioxidant, Antifungal, Antibiofilm, and Cytotoxic Activities ofMedicines (Basel, Switzerland) · 2018Review
- Antimicrobial Activity of Five Essential Oils against Bacteria and Fungi Responsible for Urinary Tract Infections.Molecules (Basel, Switzerland) · 2018Article
- The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders.Evidence-based complementary and alternative medicine : eCAM · 2018Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVaginal candidiasis is a frequent and common distressing disease affecting up to 75% of the women of fertile age; most of these women have recurrent episodes. Essential oils from aromatic plants have been shown to have antimicrobial and antifungal activities. This study was aimed at assessing the anti-fungal activity of essential oil from Mentha suaveolens (EOMS) in an experimental infection of vaginal candidiasis.
methodsThe in vitro and in vivo activity of EOMS was assessed. The in vitro activity was evaluated under standard CLSI methods, and the in vivo analysis was carried out by exploiting a novel, non-invasive model of vaginal candidiasis in mice based on an in vivo imaging technique. Differences between essential oil treated and saline treated mice were evaluated by the non-parametric Mann-Whitney U-test. Viable count data from a time kill assay and yeast and hyphae survival test were compared using the Student's t-test (two-tailed).
resultsOur main findings were: i) EOMS shows potent candidastatic and candidacidal activity in an in vitro experimental system; ii) EOMS gives a degree of protection against vaginal candidiasis in an in vivo experimental system.
conclusionsThis study shows for the first time that the essential oil of a Moroccan plant Mentha suaveolens is candidastatic and candidacidal in vitro, and has a degree of anticandidal activity in a model of vaginal infection, as demonstrated in an in vivo monitoring imaging system. We conclude that our findings lay the ground for further, more extensive investigations to identify the active EOMS component(s), promising in the therapeutically problematic setting of chronic vaginal candidiasis in humans.
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