ArticleMalaria journal2011
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage.
Article in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Antiplasmodial, Trypanocidal, and GenotoxicityPharmaceuticals (Basel, Switzerland) · 2023Article
- Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- An update on cerebral malaria for therapeutic intervention.Molecular biology reports · 2022Review
- Treatment Reducing Endothelial Activation Protects against Experimental Cerebral Malaria.Pathogens (Basel, Switzerland) · 2022Article
- Experimental Models to Study the Pathogenesis of Malaria-Associated Acute Respiratory Distress Syndrome.Frontiers in cellular and infection microbiology · 2022Review
- LncRNAs as Therapeutic Targets and Potential Biomarkers for Lipid-Related Diseases.Frontiers in pharmacology · 2021Review
- Statins: Could an old friend help in the fight against COVID-19?British journal of pharmacology · 2020Review
- Pathophysiology and neurologic sequelae of cerebral malaria.Malaria journal · 2020Review
- Effects of atorvastatin and metformin on development of pentylenetetrazole-induced seizure in mice.Heliyon · 2020Article
- The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence.PloS one · 2019Article
- Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co-cultured with Plasmodium falciparum field isolates.BMC infectious diseases · 2017Article
- 15-Lipoxygenase-1 Is Involved in the Effects of Atorvastatin on Endothelial Dysfunction.Mediators of inflammation · 2016Article
- Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.Frontiers in cellular and infection microbiology · 2015Review
- Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain.Mediators of inflammation · 2015Review
- In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum.Malaria journal · 2014Article
- Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.Journal of neuroinflammation · 2014Article
- P. falciparum isolate-specific distinct patterns of induced apoptosis in pulmonary and brain endothelial cells.PloS one · 2014Article
- Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model.Malaria journal · 2013Article
- Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier.Virulence · 2013Review
- Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model.Malaria journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders.
methodsThe effect of this compound on PRBC induced endothelial impairments was assessed using endothelial co-culture models.
resultsAtorvastatin pre-treatment of EC was found to reduce the expression of adhesion molecules and P. falciparum cytoadherence, to protect cells against PRBC-induced apoptosis and to enhance endothelial monolayer integrity during co-incubation with parasites.
conclusionsThese results might suggest a potential interest use of atorvastatin as a protective treatment to interfere with the pathophysiological cascades leading to severe malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.