Evidence map›Paper›PMID 21355841›Full record

ReviewAnti-cancer agents in medicinal chemistry2011

Texaphyrins: tumor localizing redox active expanded porphyrins.

Jonathan F Arambula, Christian Preihs, Derric Borthwick, Darren Magda, Jonathan L Sessler

Abstract readReview
In one paragraph

Review in Anti-cancer agents in medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Synthesis and Structure ofEuropean journal of organic chemistry · 2020
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan F ArambulaDepartment of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712-0165, USA.
Christian Preihs
Derric Borthwick
Darren Magda
Jonathan L Sessler

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
NCI NIH HHS CA-68682NCI NIH HHS R01 CA068682
6 · The paper itself

Abstract

Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.

Indexed as

Drug Delivery SystemsHumansNeoplasmsOxidation-ReductionPorphyrinsStructure-Activity RelationshipPorphyrinstexaphyrin

Identifiers

PMID21355841
PMCPMC3224805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.