ArticleLangmuir : the ACS journal of surfaces and colloids2011
Steering cell migration using microarray amplification of natural directional persistence.
Article in Langmuir : the ACS journal of surfaces and colloids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Shape of scaffold controlling the direction of cell migration.Biophysics and physicobiology · 2024Article
- Guiding cell adhesion and motility by modulating cross-linking and topographic properties of microgel arrays.PloS one · 2021Article
- Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns.Biophysical journal · 2020Article
- Polarity as a physiological modulator of cell function.Frontiers in bioscience (Landmark edition) · 2019Review
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Engineering Dynamic Biointerfaces.Current opinion in chemical engineering · 2016Article
- Cell-Substrate Interactions Feedback to Direct Cell Migration along or against Morphological Polarization.PloS one · 2015Article
- The cell ratchet: interplay between efficient protrusions and adhesion determines cell motion.Cell adhesion & migration · 2015Article
- Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber 'cell highways'.BMC cancer · 2014Article
- Cells as active particles in asymmetric potentials: motility under external gradients.Biophysical journal · 2014Article
- Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells.Advanced materials interfaces · 2014Article
- Geometric control of cell migration.Scientific reports · 2013Article
- Polarized neural stem cells derived from adult bone marrow stromal cells develop a rosette-like structure.In vitro cellular & developmental biology. Animal · 2013Article
- Gradient-free directional cell migration in continuous microchannels.Soft matter · 2013Article
- Micropatterning different cell types with microarray amplification of natural directional persistence.Advanced healthcare materials · 2013Article
- Directing cell migration in continuous microchannels by topographical amplification of natural directional persistence.Biomaterials · 2013Article
- Modular design of micropattern geometry achieves combinatorial enhancements in cell motility.Langmuir : the ACS journal of surfaces and colloids · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell locomotion plays a key role in embryonic morphogenesis, wound healing, and cancer metastasis. Here we show that intermittent control of cell shape using microarrays can be used to amplify the natural directional persistence of cells and guide their continuous migration along preset paths and directions. The key to this geometry-based, gradient-free approach for directing cell migration is the finding that cell polarization, induced by the asymmetric shape of individual microarray islands, is retained as cells traverse between islands. Altering the intracellular signals involved in lamellipodia extension (Rac1), contractility (RhoA), and cell polarity (Cdc42) alters the speed of fibroblast migration on these micropatterns but does not affect their directional bias significantly. These results provide insights into the role of cell morphology in directional movement and the design of micropatterned materials for steering cellular traffic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.