ArticleMolecular human reproduction2011
A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
Article in Molecular human reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.Scientific reports · 2013Pooled it
- Article
- Spatially constrained gene regulation identifies key genetic contributions of preeclampsia, hypertension, and proteinuria†.Biology of reproduction · 2023Article
- Animal Models of Cardiovascular Complications of Pregnancy.Circulation research · 2022Review
- Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China.International journal of environmental research and public health · 2021Article
- Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Article
- Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.Journal of immunology research · 2020Article
- Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms.Oxidative medicine and cellular longevity · 2019Review
- AFrontiers in psychiatry · 2018Article
- Article
- A Comparison of 2-Methoxyestradiol Value in Women with Severe Preeclampsia Versus Normotensive Pregnancy.Journal of clinical and diagnostic research : JCDR · 2017Article
- Protective Role of Maternal P.VAL158MET Catechol-O-Methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications.Journal of medical biochemistry · 2016Article
- The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes.BMC pregnancy and childbirth · 2015Article
- Proteomic analysis on the alteration of protein expression in the early-stage placental villous tissue of electromagnetic fields associated with cell phone exposure.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2013Review
- Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease.Molecular human reproduction · 2013Article
- Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients.PloS one · 2012Article
- Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.PloS one · 2012Article
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. In the present study, we have examined the COMT gene by genotyping the functional Val108/158Met polymorphism (rs4680) and an additional single-nucleotide polymorphism, rs6269, predicting COMT activity haplotypes in a large Norwegian case/control cohort (n(cases)= 1135, n(controls)= 2262). A low COMT activity haplotype is associated with recurrent preeclampsia in our cohort. This may support the role of redox-regulated signaling and oxidative stress in preeclampsia pathogenesis as suggested by recent studies in a genetic mouse model. The COMT gene might be a genetic risk factor shared between preeclampsia and cardiovascular diseases.
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