ArticleEuropean journal of cell biology2011
A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.
Article in European journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis.Cellular and molecular life sciences : CMLS · 2023Review
- Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).Investigative ophthalmology & visual science · 2023Article
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- Article
- Contribution of cell death signaling to blood vessel formation.Cellular and molecular life sciences : CMLS · 2021Review
- Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.Autophagy · 2020Article
- Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice.Scientific reports · 2019Article
- Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition.Biology open · 2019Article
- A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2018Article
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- Astrocytes in Migration.Neurochemical research · 2017Review
- CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.PloS one · 2016Article
- βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye.Biochimica et biophysica acta · 2016Review
- βA3/A1-crystallin: more than a lens protein.Progress in retinal and eye research · 2015Review
- Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.Investigative ophthalmology & visual science · 2014Article
- βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.Transgenic research · 2012Article
- βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis.Cell death & disease · 2011Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nuc1 rats migrate faster than wild type astrocytes. Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. We demonstrate that AQP4 expression is elevated in the astrocytes in PFV conditions, and we hypothesize that this causes the cells to migrate abnormally into the vitreous where they ensheath the hyaloid artery. This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.