Trial reportDental materials : official publication of the Academy of Dental Materials2011
The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin.
Trial report in Dental materials : official publication of the Academy of Dental Materials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Methods for biomimetic remineralization of human dentine: a systematic review.International journal of molecular sciences · 2015Pooled it
- Resin infiltration of non-cavitated caries lesions: a systematic review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Pooled it
- Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation.Tissue engineering and regenerative medicine · 2026Article
- Advanced biomimetic mineralization approaches for enamel and dentin regeneration: a review.Odontology · 2026Review
- Calcium ionic replacement in sodium trimetaphosphate particles: a novel strategy for bone tissue engineering.Journal of materials science. Materials in medicine · 2026Article
- Evaluation of the bond strength of glass ionomer cement modified with fluoride-loaded chitosan nanoparticles to caries-affected dentin.BMC oral health · 2025Article
- Effect of polyacrylic acid pretreatment before CPP-ACP application in remineralization of demineralized root dentin: An in vitro study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- An in-vitro evaluation of residual dentin retained after using novel enzymatic-based chemomechanical caries removal agents.Scientific reports · 2024Article
- Synthesis, Characterization, and Evaluation of the Antimicrobial Effects and Cytotoxicity of a Novel Nanocomposite Based on Polyamide 6 and Trimetaphosphate Nanoparticles Decorated with Silver Nanoparticles.Antibiotics (Basel, Switzerland) · 2024Article
- An in vitro assessment of the residual dentin after using three minimally invasive caries removal techniques.Scientific reports · 2024Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Effect of polyhydroxy-terminated PAMAM dendrimer on dentin matrix metalloproteinases within the hybrid layers.BMC oral health · 2023Article
- The Effect of Polyacrylic Acid and Sodium Trimetaphosphate on Dentin Hybrid Layer Remineralization: AnJournal of clinical and experimental dentistry · 2022Article
- Dentin anti-demineralization potential of surface reaction-type pre-reacted glass-ionomer filler containing self-adhesive resin cement.Clinical oral investigations · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- In vitro effect of toothpaste with low fluoride combined with sodium trimetaphosphate on dentine erosion.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Remineralization of Artificial Dentin LesionJournal of pharmacy & bioallied sciences · 2021Article
- In Vitro Mineralization of Collagen.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesThis study examined the use of sodium trimetaphosphate (STMP) as a biomimetic analog of matrix phosphoproteins for remineralization of artificial carious-affected dentin.
methodsArtificial carious lesions with lesion depths of 300±30μm were created by pH-cycling. 2.5% hydrolyzed STMP was applied to the artificial carious lesions to phosphorylate the partially-demineralized collagen matrix. Half of the STMP-treated specimens were bonded with One-Step. The adhesive and non-adhesive infiltrated specimens were remineralized in a Portland cement-simulated body fluid system containing polyacrylic acid (PAA) to stabilize amorphous calcium phosphate as nanoprecursors. Micro-computed tomography (micro-CT) and transmission electron microscopy (TEM) were used to evaluate the results of remineralization after a 4-month period.
resultsIn absence of PAA and STMP as biomimetic analogs (control groups), there was no remineralization irrespective of whether the lesions were infiltrated with adhesive. For the STMP-treated experimental groups immersed in PAA-containing simulated body fluid, specimens without adhesive infiltration were more heavily remineralized than those infiltrated with adhesive. Statistical analysis of the 4-month micro-CT data revealed significant differences in the lesion depth, relative mineral content along the lesion surface and changes in ΔZ between the non-adhesive and adhesive experimental groups (p<0.05 for all the three parameters). TEM examination indicated that collagen degradation occurred in both the non-adhesive and adhesive control and experimental groups after 4 months of remineralization. SIGNIFICANCE: Biomimetic remineralization using STMP is a promising method to remineralize artificial carious lesions particularly in areas devoid of seed crystallites. Future studies should consider the incorporation of MMP-inhibitors within the partially-demineralized collagen matrix to prevent collagen degradation during remineralization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.