ArticleMechanisms of ageing and development2011
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
Article in Mechanisms of ageing and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Parental Age Effects on Offspring Telomere Length Across Vertebrates: A Meta-Analysis.Molecular ecology · 2026Pooled it
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- In utero exposure to endocrine-disrupting chemicals and telomere length at birth.Environmental research · 2020Article
- Associations of parental age with offspring all-cause and cause-specific adult mortality.Scientific reports · 2019Article
- The environmental and genetic determinants of chick telomere length in Tree Swallows (Ecology and evolution · 2019Article
- The paternal age at conception effect on offspring telomere length: mechanistic, comparative and adaptive perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- No evidence for parental age effects on offspring leukocyte telomere length in free-living Soay sheep.Scientific reports · 2017Article
- Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark.European journal of epidemiology · 2017Article
- Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans.American journal of physical anthropology · 2017Article
- Overexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice.Molecular neurobiology · 2016Article
- Telomeres are elongated in older individuals in a hibernating rodent, the edible dormouse (Glis glis).Scientific reports · 2016Article
- Article
- Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring.Reproductive biology and endocrinology : RB&E · 2015Review
- Maternal and genetic factors determine early life telomere length.Proceedings. Biological sciences · 2015Article
- Leukocyte telomere length and the father's age enigma: implications for population health and for life course.International journal of epidemiology · 2013Article
- Telomeres and human reproduction.Fertility and sterility · 2013Review
- Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study.Human reproduction (Oxford, England) · 2012Article
- Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans.Molecular human reproduction · 2012Article
- Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.Biogerontology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring of older fathers. Longer telomeres might increase cancer risk. We examined the relation of father's age at the birth of the offspring (FAB) with LTL in the offspring in 2177 participants of the Family Heart Study and the probability of developing breast cancer in 1405 women from the Framingham Heart Study (offspring cohort). For each year of increase in FAB (adjusted for mother's age at birth), LTLs in the daughters and sons were longer by 19.4bp and 12.2bp, respectively (p<0.0001). Daughters of older fathers were less likely to stay free of breast cancer compared to daughters of younger fathers in empirical (p=0.014) and Cox regression analyses (p=0.0012) adjusted for relevant covariates. We conclude that older fathers endow their offspring with a longer LTL and their daughters with increased susceptibility to breast cancer. These independent observations cannot provide evidence for a causal relationship, mediated by telomere length, between FAB and increased breast cancer risk in daughters. However, with couples delaying having children in today's society, studies exploring the LTL association with increased breast cancer risk in daughters of older fathers might be timely and relevant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.