ArticleBiophysical journal2011
FCS diffusion laws in two-phase lipid membranes: determination of domain mean size by experiments and Monte Carlo simulations.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Investigation of nano- and microdomains formed by ceramide 1 phosphate in lipid bilayers.Scientific reports · 2023Article
- Quantifying membrane binding and diffusion with fluorescence correlation spectroscopy diffusion laws.Biophysical journal · 2023Article
- The Role of Ergosterol and Sphingolipids in the Localization and Activity ofInternational journal of molecular sciences · 2022Article
- Review
- Pore Forming Protein Induced Biomembrane Reorganization and Dynamics: A Focused Review.Frontiers in molecular biosciences · 2021Review
- To Hop or not to Hop: Exceptions in the FCS Diffusion Law.Biophysical journal · 2020Article
- Scaling of lipid membrane rigidity with domain area fraction.Soft matter · 2019Article
- Numerical Simulation and FRAP Experiments Show That the Plasma Membrane Binding Protein PH-EFA6 Does Not Exhibit Anomalous Subdiffusion in Cells.Biomolecules · 2018Article
- Applications of STED fluorescence nanoscopy in unravelling nanoscale structure and dynamics of biological systems.Journal of biosciences · 2018Review
- Complex dynamics at the nanoscale in simple biomembranes.Scientific reports · 2017Article
- Self assembly of HIV-1 Gag protein on lipid membranes generates PI(4,5)PScientific reports · 2016Article
- Spot variation fluorescence correlation spectroscopy allows for superresolution chronoscopy of confinement times in membranes.Biophysical journal · 2011Article
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4 authors.
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Abstract
Many efforts have been undertaken over the last few decades to characterize the diffusion process in model and cellular lipid membranes. One of the techniques developed for this purpose, fluorescence correlation spectroscopy (FCS), has proved to be a very efficient approach, especially if the analysis is extended to measurements on different spatial scales (referred to as FCS diffusion laws). In this work, we examine the relevance of FCS diffusion laws for probing the behavior of a pure lipid and a lipid mixture at temperatures below, within and above the phase transitions, both experimentally and numerically. The accuracy of the microscopic description of the lipid mixtures found here extends previous work to a more complex model in which the geometry is unknown and the molecular motion is driven only by the thermodynamic parameters of the system itself. For multilamellar vesicles of both pure lipid and lipid mixtures, the FCS diffusion laws recorded at different temperatures exhibit large deviations from pure Brownian motion and reveal the existence of nanodomains. The variation of the mean size of these domains with temperature is in perfect correlation with the enthalpy fluctuation. This study highlights the advantages of using FCS diffusion laws in complex lipid systems to describe their temporal and spatial structure.
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