Evidence map›Paper›PMID 21354374›Full record

ReviewTrends in molecular medicine2011

Cancer microRNAs: from subtype profiling to predictors of response to therapy.

Elcie Chan, Daniel Estévez Prado, Joanne Barnes Weidhaas

Abstract readReview
In one paragraph

Review in Trends in molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
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  16. Inhibition of MicroRNA miR-222 with LNA Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2017
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elcie ChanDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Daniel Estévez Prado
Joanne Barnes Weidhaas

Funding

Let-7 microRNAs in Lung Cancer: Altering Growth and RadioresistanceR01CA131301 · NCI · YALE UNIVERSITY · PI SLACK, FRANK J., WEIDHAAS, JOANNE B · 2009 to 2013
$1.7M
Defining the Genetic Basis of the Radioresponse Using a C. elegans Tissue ModelK08CA124484 · NCI · YALE UNIVERSITY · PI WEIDHAAS, JOANNE B · 2007 to 2011
$695k
NCI NIH HHS K08 CA124484NCI NIH HHS R01 CA131301
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression that regulate important oncogenes and tumor suppressors. Many miRNAs can also act as oncogenes or tumor suppressors, and thus the altered expression of miRNAs is a hallmark of many cancer types. Dysregulated miRNAs provide a potentially powerful new tool that could be used to enable the characterization of tumor environments and identify novel and important oncogenic pathways. More recently, there has been growing interest in the field of miRNAs as biomarkers of cancer risk, diagnosis and response to therapy. Understanding the associations between miRNA expression and cancer phenotypes, and the potential of miRNA profiling in clinical applications, promises to be highly rewarding in the field of cancer research.

Indexed as

Gene Expression ProfilingHumansMicroRNAsNeoplasmsPrognosisMicroRNAs

Identifiers

PMID21354374
PMCPMC3092835

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.